Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Aug 22, 2019
PMID: 31439581
The purpose of this study is to determine if inhibition of mitochondrial oxidative phosphorylation (OxPhos) is an effective strategy against MAPK pathway inhibitor (MAPKi)-resistant BRAF-mutant melanomas. The antimelanoma activity of IACS-010759 (OPi), a novel OxPhos complex I inhibitor...read more
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