A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs

Biology
Takanori EguchiKisho Ono

Abstract

Extracellular vesicles (EVs), such as exosomes or oncosomes, often carry oncogenic molecules derived from tumor cells. In addition, accumulating evidence indicates that tumor cells can eject anti-cancer drugs such as chemotherapeutics and targeted drugs within EVs, a novel mechanism of drug resistance. The EV-releasing drug resistance phenotype is often coupled with cellular dedifferentiation and transformation in cells undergoing epithelial-mesenchymal transition (EMT), and the adoption of a cancer stem cell phenotype. The release of EVs is also involved in immunosuppression. Herein, we address different aspects by which EVs modulate the tumor microenvironment to become resistant to anticancer and antibody-based drugs, as well as the concept of the resistance-associated secretory phenotype (RASP).

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Citations

May 24, 2020·International Journal of Molecular Sciences·Simona TavernaVincenza Dolo
Sep 19, 2020·International Journal of Molecular Sciences·Claudia CavallariMaria Felice Brizzi
Nov 19, 2020·Cell Death & Disease·Xingli DongYong Li
Nov 22, 2020·Journal of Clinical Medicine·Takanori Eguchi
Jan 1, 2021·Cancers·Allison A FitzgeraldLouis M Weiner
Jul 5, 2021·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Noor A HusseinAmit K Tiwari

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Methods Mentioned

BETA
flow
GTPase
protein folding

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