Jul 28, 2010

A novel model of lethal Hendra virus infection in African green monkeys and the effectiveness of ribavirin treatment

Journal of Virology
Barry RockxThomas W Geisbert

Abstract

The henipaviruses, Hendra virus (HeV) and Nipah virus (NiV), are emerging zoonotic paramyxoviruses that can cause severe and often lethal neurologic and/or respiratory disease in a wide variety of mammalian hosts, including humans. There are presently no licensed vaccines or treatment options approved for human or veterinarian use. Guinea pigs, hamsters, cats, and ferrets, have been evaluated as animal models of human HeV infection, but studies in nonhuman primates (NHP) have not been reported, and the development and approval of any vaccine or antiviral for human use will likely require efficacy studies in an NHP model. Here, we examined the pathogenesis of HeV in the African green monkey (AGM) following intratracheal inoculation. Exposure of AGMs to HeV produced a uniformly lethal infection, and the observed clinical signs and pathology were highly consistent with HeV-mediated disease seen in humans. Ribavirin has been used to treat patients infected with either HeV or NiV; however, its utility in improving outcome remains, at best, uncertain. We examined the antiviral effect of ribavirin in a cohort of nine AGMs before or after exposure to HeV. Ribavirin treatment delayed disease onset by 1 to 2 days, with no significant ben...Continue Reading

  • References27
  • Citations42

Citations

Mentioned in this Paper

Tumor Virus Infections
Pathogenic Aspects
Nipah Virus
Pathogenesis
Nonhuman primate
Cercopithecus pygerythrus
Lung
Respiratory Tract Diseases
Cercopithecus aethiops
Ferrets

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