Abstract
In an attempt to evaluate the effectiveness of a novel modified ultra-long agonist (ULA) protocol on polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI), a retrospective study of 499 women employed with either ULA or conventional long agonist (LA) protocol was analyzed. In high BMI group (>25 kg/m²), the ULA protocol yielded significant higher clinic pregnancy rate (PR) (70.2% versus 50.8%, p < 0.05), implantation rate (52.7% versus 35.7%, p < 0.05) and live birth rate (63.8% versus 39.0%, p < 0.05) when compared with LA protocol. In low BMI group (≤25 kg/m²), the ULA protocol also demonstrated a higher clinic PR (70.8% versus 59.5%, p < 0.05) whereas implantation rate and live birth rate are comparable. Within ULA protocol, the clinic PR, implantation rate and live birth rate are similar between high and low BMI patients. Similarly, the clinic PR and live birth rate demonstrated no significant difference within LA group but there is a significant lower implantation rate (35.7% versus 63.9%, p < 0.05) observed in high BMI patients. No difference in miscarriage rate and severe OHSS rate was found among all groups. In conclusion, ULA protocol benefits the IVF o...Continue Reading
References
Aug 1, 1992·Fertility and Sterility·D NavotN Laufer
Nov 1, 1994·Endocrinology·S Y ChunA J Hsueh
Nov 1, 1993·Endocrinology·H BilligA J Hsueh
Sep 18, 1998·Human Reproduction·R FlemingA Murdoch
Jun 30, 2000·Human Reproduction·R FlemingH Lyall
Nov 25, 2000·BMJ : British Medical Journal·J X WangR J Norman
Jun 12, 2002·Fertility and Sterility·Zeev Shoham
Aug 21, 2004·Human Reproduction·Péter FedorcsákTom Tanbo
Jun 14, 2005·Fertility and Sterility·Allison Styne-GrossRichard T Scott
Jan 19, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Herve DechaudBernard Hedon
Oct 11, 2007·The Journal of Clinical Endocrinology and Metabolism·Bulent O YildizRicardo Azziz
Nov 6, 2007·Fertility and Sterility·Jan W van der SteegUNKNOWN Collaborative Effort for Clinical Evaluation in Reproductive Medicine Study Group
Nov 16, 2007·Biology of Reproduction·K A WaltersD J Handelsman
Jun 14, 2008·Reproductive Biomedicine Online·Ioannis MatalliotakisAydin Arici
Jul 5, 2008·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Rebecca L Robker
Sep 9, 2008·Fertility and Sterility·Raoul OrvietoJacob Ashkenazi
Sep 20, 2008·Journal of Assisted Reproduction and Genetics·Rafal KurzawaPawel Brelik
Jun 23, 2009·Journal of Endocrinological Investigation·G TargherP Moghetti
Apr 17, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Christopher J Brewer, Adam H Balen
Mar 2, 2012·Reproductive Biomedicine Online·M Al-AzemiH M Fatemi
Mar 9, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Roberto MarciMassimo Moscarini
Mar 30, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Zahra HaghighiSomayyeh Es-Haghi Ashtiani
May 9, 2012·Human Reproduction·Chu-Chun HuangYu-Shih Yang
Nov 2, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S S LimL J Moran