A novel motion analysis approach reveals late recovery in C57BL/6 mice and deficits in NCAM-deficient mice after sciatic nerve crush

Journal of Neurotrauma
Andreas FeyAndrey Irintchev

Abstract

Assessment of motor abilities after sciatic nerve injury in rodents, in particular mice, relies exclusively on walking track (footprint) analysis despite known limitations of this method. Using principles employed recently for video-based motion analyses after femoral nerve and spinal cord injuries, we have designed and report here a novel approach for functional assessments after sciatic nerve lesions in mice. Functional deficits are estimated by angle and distance measurements on single video frames recorded during beam-walking and inclined ladder climbing. Analyses of adult C57BL/6J mice after crush of the sciatic, tibial, or peroneal nerve allowed the identification of six numerical parameters, detecting impairments of the plantar flexion of the foot and the toe spread. Some of these parameters, as well as footprint functional indices, revealed severe impairment after crush injury of the sciatic or tibial, but not the peroneal nerve, and complete recovery within 3 weeks after lesion. Other novel estimates, however, showed that complete recovery is reached as late as 2-3 months after sciatic nerve crush. These measures detected both tibial and peroneal dysfunction. In contrast to the complete restoration of function in wild-...Continue Reading

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Citations

Apr 13, 2011·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Andrey Irintchev
Jun 28, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Krisztina BorosPéter Sántha
May 15, 2016·The European Journal of Neuroscience·Vedangana SainiIgor Jakovcevski
Feb 26, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Wenyan SunShusheng Gong
Feb 1, 2017·The Journal of Cell Biology·Thomas MindosDavid B Parkinson
Sep 1, 2018·Aging Cell·Robert BüttnerHelen Morrison
Sep 10, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Andrey Irintchev, Melitta Schachner
May 4, 2021·Frontiers in Neuroscience·Alec T BeeveErica L Scheller

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Methods Mentioned

BETA
dissection

Software Mentioned

SIMI
ImageTool
Motion
VirtualDub
CatWalk

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