A novel multidrug-resistance protein 2 gene mutation identifies a subgroup of patients with primary biliary cirrhosis and pruritus

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Annarosa FloreaniN V Bergasa

Abstract

A single nucleotide polymorphism characterized by the substitution of valine for glutamate (V1188E) in exon 25 of the multidrug resistance protein 2 gene was found in a group of patients with primary biliary cirrhosis. This heterozygous mutation was significantly associated with the presence of pruritus.

References

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Oct 25, 2003·Oncogene·Gary D Kruh, Martin G Belinsky
Nov 25, 2003·Gut·C G DietrichR P J Oude Elferink
Dec 10, 2003·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Junichi ShodaNaomi Tanaka
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Mar 30, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Olivier FardelLea Payen

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Citations

Sep 5, 2009·Journal of Gastroenterology·Annarosa FloreaniNora V Bergasa
Sep 28, 2014·Expert Opinion on Drug Metabolism & Toxicology·Christoph G Dietrich, Andreas Geier
Jul 20, 2011·Seminars in Cutaneous Medicine and Surgery·Nora V Bergasa
May 6, 2008·Clinics in Liver Disease·Nora V Bergasa
Dec 16, 2010·Journal of Gastroenterology and Hepatology·Klaus EisendleReinhard Höpfl
Jan 7, 2018·Scandinavian Journal of Gastroenterology·Luise AamannDorte Launholt Lildballe
Nov 1, 2008·Drug Metabolism and Pharmacokinetics·Woon Fei HoJon Deoon Lee

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