A Novel Multimodal NIR-II Nanoprobe for the Detection of Metastatic Lymph Nodes and Targeting Chemo-Photothermal Therapy in Oral Squamous Cell Carcinoma

Theranostics
Yufeng WangWei Han

Abstract

Current surgical treatment for oral squamous cell carcinoma (OSCC) must be as precise as possible to fully resect tumors and preserve functional tissues. Thus, it is urgent to develop efficient fluorescent probes to clearly identify tumor delineation, as well as metastatic lymph nodes. Chemo-photothermal therapy combination attracted a growing attention to increase anti-tumor effect in various types of cancer, including OSCC. In the present study, we designed a multimodal NIR-II probe that involves combining photothermal therapy with chemotherapy, imaging OSCC tumors and detecting metastatic lymph nodes. Methods: In this study, we synthesized a novel near infrared (NIR)-II probe named TQTPA [4,4'-((6,7-bis(4-(hexyloxy)phenyl)-[1,2,5]thiadiazolo [3,4-g]quinoxaline-4,9-diyl)bis(thiophene-5,2-diyl))bis(N,N-diphenylaniline)] via the Suzuki reaction and prepared multimodal nanoparticles (NPs) loading TQTPA and cis-dichlorodiammine platinum (CDDP) (HT@CDDP) by hyaluronic acid. The characteristics of the NPs, including their photothermal and imaging capabilities were investigated in vitro and in vivo. Their anti-tumor efficacy was evaluated using orthotopic, tongue tumor-bearing, nude mice. Results: The NPs possessed good stability an...Continue Reading

Citations

Sep 15, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jiaxin ZuoPing Xiong
Mar 13, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Nicholas E Wojtynek, Aaron M Mohs
Dec 29, 2020·International Journal of Nanomedicine·Jinghua SunRuiping Zhang
Apr 23, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huihui ZouWei Han
Jul 21, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mengqin GuXiyu Li

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Methods Mentioned

BETA
dissection
xenograft
NMR
dynamic
transmission electron microscopy
light scattering
irradiate
fluorescence imaging
nanoprecipitation
flow cytometry

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