A novel myeloid-restricted zebrafish CCAAT/enhancer-binding protein with a potent transcriptional activation domain.

Blood
Susan E LyonsP P Liu

Abstract

The CCAAT/enhancer-binding protein (C/EBP) family consists of transcription factors essential for hematopoiesis. The defining feature of the C/EBPs is a highly conserved carboxy-terminal bZIP domain that is necessary and sufficient for dimerization and DNA binding, whereas their amino-terminal domains are unique. This study reports a novel c/ebp gene (c/ebp1) from zebrafish that encodes a protein homologous to mammalian C/EBPs within the bZIP domain, but with an amino terminus lacking homology to any C/EBP or to any known sequence. In zebrafish embryos, c/ebp1 expression was initially observed in cells within the yolk sac circulation valley at approximately the 16-to 18-somite stage, and at 24 hours postfertilization (hpf), also in circulating cells. Most c/ebp1(+) cells also expressed a known early macrophage marker, leukocyte-specific plastin (l-plastin). Expression of both markers was lost in cloche, a mutant affecting hematopoiesis at the level of the hemangioblast. Expression of both markers was retained in m683 and spadetail, mutants affecting erythropoiesis, but not myelopoiesis. Further, c/ebp1 expression was lost in a mutant with defective myelopoiesis, but intact erythropoiesis. These data suggest that c/ebp1 is expre...Continue Reading

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Citations

Sep 19, 2001·Current Opinion in Hematology·K HsuA T Look
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Susan E LyonsP Paul Liu
Jan 28, 2014·The Science of the Total Environment·Nancy BlüthgenKarl Fent
Jul 25, 2014·The International Journal of Biochemistry & Cell Biology·Maria-Cristina KeightleyGraham J Lieschke
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Jan 30, 2007·Experimental Hematology·Ting Xi LiuA Thomas Look
Aug 19, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Susov DhakalDeborah L Stenkamp
Nov 18, 2003·British Journal of Haematology·Jason BermanA Thomas Look
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Oct 8, 2005·The Journal of Biological Chemistry·Marianne A JuarezSusan E Lyons
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