A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mapping

Genomics
R KubotaN Shimizu

Abstract

We have isolated a human cDNA clone encoding a novel acidic protein of MW 55,000 that we designated "myocilin" since it has homology to myosin and is localized preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells. The deduced amino acid sequence of human myocilin showed significant homologies with nonmuscle myosin of Dictyostelium discoideum in the N-terminal region and also with olfactomedin of bullfrog in the C-terminal region. Myocilin contained a leucine zipper-like motif similar to that seen in kinectin and other cytoskeletal proteins. These findings suggest that myocilin is a novel cytoskeletal protein involved in the morphogenesis of ciliated neuroepithelium such as photoreceptor cells. The myocilin gene (MYOC) was mapped to human chromosome 1q23-q24 by fluorescence in situ hybridization.

References

Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W R Pearson, D J Lipman
Jan 1, 1986·Cell Motility and the Cytoskeleton·J L SalisburyM A Sanders
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H M WarrickJ A Spudich
Mar 1, 1986·Archives of Ophthalmology·D G HunterF L Kretzer
Jan 1, 1981·Bioscience Reports·F Sanger
Dec 11, 1981·Science·F Sanger
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·T HassonM S Mooseker
Feb 1, 1995·Current Opinion in Cell Biology·J L Salisbury
Feb 1, 1995·Molecular Biology of the Cell·A FüttererM Krönke
Jan 1, 1993·Cell Motility and the Cytoskeleton·J B RattnerT J Yen
Dec 1, 1993·The Japanese Journal of Human Genetics·Y WangN Shimizu
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·H Yokoe, R R Anholt
May 20, 1997·Gene·S AsakawaN Shimizu

❮ Previous
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Citations

Aug 18, 2000·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·L KirsteinE R Tamm
Mar 13, 2009·The New England Journal of Medicine·Young H KwonWallace L M Alward
Nov 5, 1999·Human Molecular Genetics·Z Zhou, D Vollrath
Dec 10, 1998·Nucleic Acids Research·S MinoshimaN Shimizu
Oct 22, 2008·International Ophthalmology Clinics·Pratap Challa
Dec 24, 1998·Journal of Medical Genetics·D StoilovaM Sarfarazi
Sep 3, 2010·The Journal of Clinical Investigation·Bao Jian Fan, Janey L Wiggs
May 23, 2012·PloS One·K David KennedyTeresa Borrás
Dec 25, 2013·PloS One·Brian S McKayW Daniel Stamer
Mar 21, 2001·Pharmacogenomics·H T Steely, A F Clark
Dec 22, 2010·Indian Journal of Ophthalmology·Kollu N RaoSubhabrata Chakrabarti
Feb 1, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Charles N J McGheeHelen Danesh-Meyer
Dec 12, 2012·Survey of Ophthalmology·Gerassimos LascaratosDavid F Garway-Heath
Oct 12, 2010·Experimental Eye Research·Zachary T ReschMichael P Fautsch
Nov 1, 2008·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Benoît LabrecqueMarie-France Palin
Sep 23, 2008·Experimental Eye Research·Zachary T Resch, Michael P Fautsch
Aug 5, 2008·Experimental Eye Research·Mohamed-Karim EzzatMichael P Fautsch
May 15, 2007·American Journal of Ophthalmology·Mary K WirtzN Donna Gaudette
Nov 11, 2006·Experimental Eye Research·K M PerkumasW D Stamer
May 12, 2004·Journal of Cellular Physiology·Kelly Wentz-HunterBeatrice Y J T Yue
Aug 27, 2005·Pediatrics International : Official Journal of the Japan Pediatric Society·Nobuhiko OkamotoNaomichi Matsumoto
Aug 19, 2015·The Veterinary Clinics of North America. Small Animal Practice·András M Komáromy, Simon M Petersen-Jones
Feb 3, 2004·American Journal of Medical Genetics. Part a·Yoshiki TodaZentaro Yamagata
Apr 26, 2008·Veterinary Ophthalmology·E O MackayK N Gelatt
Oct 30, 2007·Human Mutation·Alex W HewittJamie E Craig
Nov 29, 2007·Veterinary Ophthalmology·Kumiko KatoHiroyuki Ogawa
Feb 13, 2013·Journal of Medical Primatology·I P Rodríguez-SánchezH A Barrera-Saldaña
Jan 11, 2002·Developmental Biology·T A Moreno, M Bronner-Fraser
Nov 30, 2000·Experimental Eye Research·P V RaoD L Epstein
Jun 15, 2004·Experimental Cell Research·Kelly Wentz-HunterBeatrice Y J T Yue
Sep 16, 2006·Experimental Eye Research·W D StamerB S McKay
Dec 8, 2005·Clinical Biochemistry·Bao Jian FanChi Pui Pang
Nov 18, 2005·Experimental Eye Research·Michael P FautschDouglas H Johnson
Jan 5, 2002·American Journal of Human Genetics·Andrea L VincentElise Héon
Dec 19, 2003·Biochemical and Biophysical Research Communications·Myung Kuk JoeChangwon Kee
May 20, 1998·Biochemical and Biophysical Research Communications·S I TomarevB Chang
Dec 3, 2014·Experimental Eye Research·Jennifer A FaralliDonna M Peters
Apr 25, 2015·Survey of Ophthalmology·Lance P DoucetteMichael A Walter

❮ Previous
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