A novel nasal almotriptan loaded solid lipid nanoparticles in mucoadhesive in situ gel formulation for brain targeting: Preparation, characterization and in vivo evaluation

International Journal of Pharmaceutics
Nancy Abdel Hamid Abou YoussefNabila Ahmed Boraie

Abstract

This work aimed at designing efficient safe delivery system for intranasal (IN) brain targeting of the water soluble anti- migraine drug Almotriptan malate (ALM). Solid lipid nanoparticles (SLNs) were prepared by w/o/w double emulsion-solvent evaporation method. Selection of the optimized SLNs formula was based on evaluating particle size (PS), poly dispersity index (PDI) and entrapment efficiency (%EE). Optimized formula exhibited acceptable ranges; PS of 207.9 nm, PDI of 0.41 and %EE of 50.81%. Poloxamer 407 (Plx) at different concentrations (16%, 18%, 20% w/v), with different mucoadhesive polymers (Carbopol-974P, Na alginate, Na-CMC) were evaluated for gelling time and temperature, pH and mucoadhesion. The chosen mucoadhesive in-situ gel formula; 18% Plx 407 based-0.75%w/v Na-CMC, showed acceptable results, so that the optimized SLNs formula was further dispersed in it and evaluated for in vitro release, stability, in vivo and pharmacokinetics studies. Biomarkers' evaluation and histopathological examination were also investigated. Results revealed rapid ALM brain delivery of the optimized formula; Brain/blood ratios at 10 min. for NF (SLNs based IN in-situ gel), ND (Free ALM IN in situ gel) and ALM i.v. (ALM IV solution) we...Continue Reading

Citations

Sep 5, 2019·Current Pharmaceutical Design·Kuldeep Rajpoot
Jul 1, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Sravanthi Reddy PaillaSunitha Sampathi
Jul 4, 2020·Drug Delivery and Translational Research·Shaimaa MakledNoha Nafee
Feb 12, 2020·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Anroop B NairTamer M Shehata
Nov 17, 2020·Frontiers in Molecular Biosciences·Sebastián Scioli MontotoMaría Esperanza Ruiz
Feb 6, 2021·Pharmaceutics·Anna FroelichBozena Michniak-Kohn
Apr 22, 2020·Brain Research Bulletin·Seetha HarilalBijo Mathew
Apr 25, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chinazom Precious AgboKenneth Chibuzor Ofokansi
Aug 3, 2021·International Journal of Nanomedicine·Eman AbdelhakeemRehab Shamma
Nov 21, 2021·Neurochemical Research·Thuy Trang NguyenGiau Van Vo
Dec 28, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Robert A Yokel

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