A novel nomogram individually predicting disease-specific survival after D2 gastrectomy for advanced gastric cancer

Cancer Communications
Wei WangZhi-Wei Zhou

Abstract

Few studies have shown nomograms that may predict disease-specific survival (DSS) probability after curative D2 gastrectomy for advanced gastric cancer (AGC), particularly among Chinese patients. This study sought to develop an elaborative nomogram that predicts long-term DSS for AGC in Chinese patients. A retrospective study was conducted on 6753 AGC patients undergoing D2 gastrectomy between January 1, 2000 and December 31, 2012 from three large medical hospitals in China. We assigned patients from Sun Yat-sen University Cancer Center to the training set, and patients from the First Affiliated Hospital of China Medical University and Tianjin Medical University Cancer Hospital to two separate external validation sets. A multivariate survival analysis was performed using Cox proportional hazards regression model in a training set, and a nomogram was constructed. Harrell's C-index was used to evaluate discrimination and calibration plots were used to validate similarities between survival probabilities predicted by the nomogram model and actual survival rates in two validation sets. The multivariate Cox regression model identified age, tumor size, location, Lauren classification, lymphatic/venous invasion, depth of invasion, and...Continue Reading

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Citations

Oct 28, 2019·Cancer Communications·Jincheng FengKatrin Hoffmann
Jun 9, 2020·Annals of Surgical Oncology·Guo-Ming ChenYing-Bo Chen
Jan 1, 2021·Bioorganic Chemistry·Xin-Hui ZhangHong-Min Liu
Jan 30, 2021·World Journal of Gastrointestinal Oncology·Dong-Yan ZhaoShu-Kun Yao
Aug 17, 2021·Chemical Biology & Drug Design·Zhongqing WangQing Lin
Oct 1, 2021·Recent Patents on Anti-cancer Drug Discovery·Sheng-Xiong ZhangLi-Zhu Lin

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Software Mentioned

R
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