A novel nomogram to identify candidates for active surveillance amongst patients with International Society of Urological Pathology (ISUP) Grade Group (GG) 1 or ISUP GG2 prostate cancer, according to multiparametric magnetic resonance imaging findings

BJU International
Stefano LuzzagoGennaro Musi

Abstract

To develop a novel nomogram to identify candidates for active surveillance (AS) that combines clinical, biopsy and multiparametric magnetic resonance imaging (mpMRI) findings; and to compare its predictive accuracy to, respectively: (i) Prostate Cancer Research International: Active Surveillance (PRIAS) criteria, (ii) Johns Hopkins (JH) criteria, (iii) European Association of Urology (EAU) low-risk classification, and (iv) EAU low-risk or low-volume with International Society of Urological Pathology (ISUP) Grade Group (GG) 2 classification. We selected 1837 patients with ISUP GG1 or GG2 prostate cancer (PCa), treated with radical prostatectomy (RP) between 2012 and 2018. The outcome of interest was the presence of unfavourable disease (i.e., clinically significant PCa [csPCa]) at RP, defined as: ISUP GG ≥ 3 and/or pathological T stage (pT) ≥3a and/or pathological N stage (pN) 1. First, logistic regression models including PRIAS, JH, EAU low-risk, and EAU low-risk or low-volume ISUP GG2 binary classifications (not eligible vs eligible) were used. Second, a multivariable logistic regression model including age, prostate-specific antigen density (PSA-D), ISUP GG, and the percentage of positive cores (Model 1) was fitted. Third, ...Continue Reading

References

Feb 24, 2009·The Journal of Urology·Simon L ContiPeter R Carroll
Apr 6, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey J TosoianH Ballentine Carter
Feb 11, 2012·European Radiology·Jelle O BarentszUNKNOWN European Society of Urogenital Radiology
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Dec 17, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laurence KlotzAndrew Loblaw
Jan 27, 2015·Urologic Oncology·Giorgio GandagliaUNKNOWN Prostate Cancer Working Group of Young Academic Urologists Working Party of European Association of Urology
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May 18, 2018·BJU International·Giorgio GandagliaUNKNOWN European Association of Urology Young Academic Urologists Working Party on Prostate Cancer (EAU-YAUWP)

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Citations

Dec 9, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Joseba SalgueroMaría José Requena
Jul 31, 2020·Tumori·Hakan Bahadir HaberalHaluk Ozen
Dec 23, 2020·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·F RozetA Méjean

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