A novel non-invasive method to assess aortic valve opening in HeartMate II left ventricular assist device patients using a modified Karhunen-Loève transformation

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Corey J BishopBruce B Reid

Abstract

Thrombus formation on or near the aortic valve has been reported in HeartMate II (Thoratec, Pleasanton, CA) left ventricular assist device (LVAD) patients whose aortic valves do not open. With an akinetic valve, thrombogenesis is more likely. Thrombus formation may lead to neurologic events, placing the patient at greater risk. Aortic valve stenosis and/or regurgitation have also been observed with akinetic aortic valves. Assessing aortic valve opening is crucial when optimizing rotations per minute (rpm) to minimize embolic risk and aortic valve stenosis but presently relies solely on echocardiography, intermittent decreases in rpms to force aortic valve opening, and monitoring of pulse pressure. We hypothesized the electrical current waveforms of the HeartMate II would reveal whether the aortic valve was opening due to pressure changes in the left ventricle to allow for continuous monitoring and control of aortic valve opening ratios. Electrical HeartMate II current waveforms of patients from 2008 to 2009 that were recorded at the time of echocardiograph procedures were analyzed using a modified Karhunen-Loève transformation with a training set of electrical waveforms from 8,860 HeartMate II electrical current recordings from...Continue Reading

References

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Oct 18, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Thorsten DrewsRoland Hetzer
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May 7, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Timothy J MyersO H Howard Frazier

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Citations

Oct 10, 2013·Artificial Organs·Marcus GraneggerFrancesco Moscato
Jan 16, 2014·Artificial Organs·Hui-Lee OoiNigel H Lovell
Jul 2, 2015·Chemical Communications : Chem Comm·C J BishopJ J Green
Oct 16, 2015·IEEE Transactions on Bio-medical Engineering·Marcus GraneggerFrancesco Moscato
Mar 18, 2015·IEEE Journal of Biomedical and Health Informatics·Hui-Lee OoiEinly Lim
Jan 23, 2014·Circulation. Heart Failure·Teresa S WangChetan B Patel
Oct 31, 2018·Artificial Organs·Rachel CliffordChristopher S Hayward
Jan 26, 2020·General Thoracic and Cardiovascular Surgery·Jesse F Veenis, Jasper J Brugts
Jan 8, 2014·Current Opinion in Cardiology·Hadi Daood ToegMarc Ruel

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