A novel one-pot four-component access to tetrahydro-beta-carbolines by a coupling-amination-aza-annulation-Pictet-Spengler sequence (CAAPS)

Chemical Communications : Chem Comm
Alexei S KarpovThomas J J Müller

Abstract

The four-component coupling-amination-aza-annulation-Pictet-Spengler (CAAPS) sequence of acid chlorides 1, terminal alkynes 2, tryptamine derivatives 6, and acryloyl chloride derivatives 4 represents a facile and rapid one-pot access to tetrahydro-beta-carbolines 7 in moderate to good yields.

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Feb 15, 2003·The Journal of Organic Chemistry·Alexei S KarpovThomas J J Müller
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Citations

Mar 7, 2012·Chemical Reviews·Morteza Shiri
Jun 20, 2007·Chemical Society Reviews·Daniel M D'Souza, Thomas J J Müller
Jan 21, 2010·Chemical Communications : Chem Comm·Wei WangAlexander Dömling
Nov 1, 2013·Chemistry : a European Journal·Xiao-Feng WuMatthias Beller
Jan 6, 2011·Chemistry : a European Journal·Xiao-Feng WuMatthias Beller
Nov 18, 2004·Angewandte Chemie·Christoph J Kressierer, Thomas J J Müller
May 19, 2005·Chemical Communications : Chem Comm·Alexei S KarpovThomas J J Müller
Sep 18, 2010·Chemistry : a European Journal·Xiao-Feng WuMatthias Beller
Dec 6, 2005·Organic & Biomolecular Chemistry·Alexei S KarpovThomas J J Müller
Mar 10, 2007·Chemical Communications : Chem Comm·Eugen Merkul, Thomas J J Müller
Feb 20, 2007·Chemical Reviews·Rafael Chinchilla, Carmen Najera
May 13, 2009·Organic Letters·Eugen MerkulThomas J J Müller
Oct 24, 2019·Chemical Reviews·Carmen NájeraMiguel Yus
Aug 14, 2013·The Journal of Organic Chemistry·Song LiuSergey A Kozmin

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