A novel oocyte maturation trigger using 1500 IU of human chorionic gonadotropin plus 450 IU of follicle-stimulating hormone may decrease ovarian hyperstimulation syndrome across all in vitro fertilization stimulation protocols

Journal of Assisted Reproduction and Genetics
Yanett AnayaMitchell P Rosen

Abstract

Modification of the trigger used to induce final oocyte maturation in in vitro fertilization (IVF) is a major strategy used to reduce the risk of ovarian hyperstimulation syndrome (OHSS). A novel trigger composed of 1500 IU of human chorionic gonadotropin (hCG) plus 450 IU of follicle-stimulating hormone (FSH) has been developed to reduce OHSS risk. This study compares outcomes of the novel trigger to conventional triggers used in high-risk OHSS patients undergoing IVF. In this retrospective cohort study, IVF cycles at high risk for OHSS based on a serum estradiol > 5000 pg/ml on trigger day conducted between January 2008 and February 2016 were evaluated. Oocyte maturation was induced with the novel trigger (1500 IU hCG plus 450 IU FSH) or a conventional trigger [3300 IU hCG, gonadotropin-releasing hormone agonist (GnRHa) alone, or GnRHa plus 1500 IU hCG]. IVF cycle outcomes were compared. Trigger strategies were examined for associations with OHSS development using logistic regression. Among 298 eligible IVF cycles identified, there were no differences in oocyte maturation, fertilization, embryo quality, or pregnancy outcomes among all triggers. After adjusting for serum estradiol level and number of follicles, the novel trigg...Continue Reading

References

Sep 1, 1978·Fertility and Sterility·J G Schenker, D Weinstein
Jul 1, 1975·Obstetrics and Gynecology·J G Schenker, W Z Polishuk
Oct 1, 1992·Journal of Assisted Reproduction and Genetics·P A Bergh, D Navot
Sep 1, 1991·The Journal of Clinical Endocrinology and Metabolism·M B Zelinski-WootenR L Stouffer
Oct 1, 1990·The Journal of Clinical Endocrinology and Metabolism·Y GonenR F Casper
Jun 1, 1989·Obstetrical & Gynecological Survey·A GolanE Caspi
Apr 1, 1989·Journal of in Vitro Fertilization and Embryo Transfer : IVF·R T ScottZ Rosenwaks
Sep 1, 1989·Fertility and Sterility·M D DamewoodE E Wallach
Aug 1, 1989·Human Reproduction·O Bomsel-HelmreichI Durand-Gasselin
Jul 1, 1988·American Journal of Obstetrics and Gynecology·D NavotE J Margalioth
Mar 1, 1968·The Journal of Clinical Investigation·D S SchalchS Reichlin
Dec 1, 1968·The Journal of Clinical Endocrinology and Metabolism·S S YenO H Pearson
Jan 1, 1969·The Journal of Clinical Endocrinology and Metabolism·T RizkallahR L Vande Wiele
Dec 1, 1984·Journal of in Vitro Fertilization and Embryo Transfer : IVF·B SmithI Craft
Oct 1, 1983·The Journal of Clinical Endocrinology and Metabolism·J D HoffS S Yen
May 1, 1993·Human Reproduction·J G Schenker
Jun 1, 1997·Human Reproduction·U Elchalal, J G Schenker
Dec 3, 1998·The Journal of Clinical Investigation·E R LevinA Pedram
Apr 15, 1999·Fertility and Sterility·Y AbramovJ G Schenker
Jul 28, 1999·Molecular Human Reproduction·C Yding AndersenA G Byskov
Feb 26, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A Z Işik, K Vicdan
Jul 13, 2001·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·D GrochowskiM Szamatowicz
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Tzu-Hao WangYung-Kuei Soong
Dec 10, 2002·Reproductive Biomedicine Online·C Yding Andersen
Dec 25, 2002·Human Reproduction Update·Annick Delvigne, Serge Rozenberg

❮ Previous
Next ❯

Citations

Jul 31, 2021·American Journal of Perinatology·Shirah Vainer-RotbartAmalia Levy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.