PMID: 9523551Apr 2, 1998Paper

A novel orphan G protein-coupled receptor primarily expressed in the brain is localized on human chromosomal band 2q21

Journal of Neurochemistry
R BläsiusA Ogilvie

Abstract

A human hippocampus cDNA library was screened with a probe obtained from degenerate RT-PCR aimed at P2Y-homologous sequences. A positive clone, designated hip4, was identified containing an open reading frame of 1,020 bp that had been previously detected in a published genomic clone called R12. Subsequent screening of a human fetal brain cDNA library yielded a splice variant with a 1,104-bp open reading frame, which was named fb1. Both variants display the seven-transmembrane topology that is typical for G protein-coupled receptors. Probing a human multitissue northern blot revealed two brain-specific transcripts of 2.3 and 6.3 kb, respectively. Northern blot analyses with specific fragments confirmed that the two transcripts are generated by alternative polyadenylation yielding two different 3' untranslated regions. A genomic clone from the corresponding gene was isolated and mapped to human chromosomal band 2q21 by fluorescence in situ hybridization.

Citations

Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Christophe HuberLudwig Aigner
Mar 22, 2012·Medicinal Research Reviews·Valérie CapraG Enrico Rovati
Jun 30, 2009·Proceedings of the National Academy of Sciences of the United States of America·Akiko MaekawaYoshihide Kanaoka
Jul 25, 2009·American Journal of Physiology. Cell Physiology·Anna Maria PuglieseMaria P Abbracchio
Mar 4, 2017·Molecular Pharmacology·Katharina SimonEvi Kostenis
Jan 15, 2019·Expert Opinion on Therapeutic Patents·Gabriella MarucciMichela Buccioni
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Jul 27, 2021·Journal of Medicinal Chemistry·Phung NguyenMeenakshisundaram Kandhavelu
Apr 30, 2011·Chemical Reviews·Motonao Nakamura, Takao Shimizu
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