A novel P22 prophage in Salmonella typhimurium.

Genetics
D M Downs, J R Roth

Abstract

Under several sets of conditions, all of which seem to perturb purine metabolism, Salmonella typhimurium releases a variety of phages which were not known to be present in the strain. These cryptic phages are not induced by UV irradiation. Furthermore, the induction process does not require a functional recA gene product. While phages of several phenotypic classes have been recovered, including both turbid and clear plaque formers, all appear to be variants of P22 because all show DNA restriction patterns indistinguishable from that of P22. The variety of types suggests that the cryptic prophage is mutagenized as a consequence of the induction process. All the temperature phages tested are capable of transducing a variety of chromosomal markers with high efficiency. The phages induced in this novel way are capable of forming plaques on the strains that gave rise to them. Since the strains releasing phage are not immune to P22, the parental lysogens must not express immunity and the phage must be held in a cryptic state by a novel mechanism. The released phage possess an intact P22 immunity system because many can form standard immune lysogens after reinfection of Salmonella. These results raise the possibility that Salmonella t...Continue Reading

Citations

Oct 1, 1991·Journal of Bacteriology·D M Downs, J R Roth
Dec 1, 1990·Microbiological Reviews·S Krawiec, M Riley
Sep 2, 2005·Nature·Animesh Ray
Aug 1, 1992·The Journal of Applied Bacteriology·D L ReadK McCann
Jan 1, 1989·Environmental and Molecular Mutagenesis·J W Drake
Jul 1, 1989·Journal of Bacteriology·C M Smith, E Eisenstadt
Dec 22, 2020·The ISME Journal·Anna DragošÁkos T Kovács
Dec 1, 1988·Microbiological Reviews·K E Sanderson, J R Roth
Apr 1, 1988·Trends in Biochemical Sciences·M B Schmid

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