A Novel Peroxisome Proliferator-activated Receptor (PPAR)γ Agonist 2-Hydroxyethyl 5-chloro-4,5-didehydrojasmonate Exerts Anti-Inflammatory Effects in Colitis.

The Journal of Biological Chemistry
Jieun ChooEunok Im

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disease with increasing incidence and prevalence worldwide. Here we investigated the newly synthesized jasmonate analogue 2-hydroxyethyl 5-chloro-4,5-didehydrojasmonate (J11-Cl) for its anti-inflammatory effects on intestinal inflammation. First, to test whether J11-Cl can activate peroxisome proliferator-activated receptors (PPARs), we performed docking simulations because J11-Cl has a structural similarity with anti-inflammatory 15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2), one of the endogenous ligands of PPARγ. J11-Cl bound to the ligand binding domain of PPARγ in the same manner as 15d-PGJ2 and rosiglitazone, and significantly increased transcriptional activity of PPARγ. In animal experiments, colitis was significantly reduced in mice with J11-Cl treatment, determined by analyses of survival rate, body weight changes, clinical symptoms, and histological evaluation. Moreover, J11-Cl decreased production of pro-inflammatory cytokines including IL-6, IL-8, and G-CSF as well as chemokines including chemokine (C-C motif) ligand (CCL)20, chemokine (C-X-C motif) ligand (CXCL)2, CXCL3, and chemokine (C-X3-C motif) ligand 1 (CX3CL1) in colon tissues, and LPS or TNF-α-stimu...Continue Reading

References

Jan 3, 2001·The Journal of Clinical Investigation·P P Tak, G S Firestein
Feb 19, 2002·Immunology·Dino Rotondo, Jillian Davidson
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Georg H WaetzigStefan Schreiber
Apr 17, 2003·The Journal of Surgical Research·Marshall S BakerDixon B Kaufman
Aug 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eike HollenbachMichael Naumann
Jan 5, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bhavani Prasad KotaBasil D Roufogalis
Feb 1, 2005·Alimentary Pharmacology & Therapeutics·J PulestonA Platt
Nov 30, 2006·Pharmacological Reviews·Liliane MichalikWalter Wahli
May 4, 2007·Inflammatory Bowel Diseases·Jonas Mudter, Markus F Neurath
Jul 27, 2007·Nature·R J Xavier, D K Podolsky
Oct 13, 2007·Inflammatory Bowel Diseases·Satheesh K SainathanBrian K Dieckgraefe
Nov 6, 2007·Trends in Immunology·Daniel S Straus, Christopher K Glass
May 16, 2008·Journal of Internal Medicine·I AtreyaM F Neurath
Nov 11, 2008·Bioorganic & Medicinal Chemistry·Hung The DangJee H Jung
Oct 2, 2009·Clinical and Experimental Immunology·O J BroomO H Nielsen
Nov 12, 2009·Current Gastroenterology Reports·David Q Shih, Stephan R Targan
Nov 4, 2011·The New England Journal of Medicine·Silvio Danese, Claudio Fiocchi
May 29, 2012·Bioorganic & Medicinal Chemistry·Hung The DangJee H Jung
Aug 24, 2012·Lancet·Daniel C Baumgart, William J Sandborn
Sep 20, 2012·Nature Immunology·Jacques BanchereauAnne O'Garra
Nov 10, 2012·World Journal of Gastroenterology : WJG·Györgyi MűzesFerenc Sipos
Jan 18, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laia EgeaMartin F Kagnoff
Feb 26, 2013·Nature Reviews. Immunology·Elzbieta Kolaczkowska, Paul Kubes
Mar 22, 2014·International Journal of Cell Biology·Italo Mario CesariFranklin David Rumjanek
Apr 23, 2014·Nature Reviews. Immunology·Markus F Neurath

❮ Previous
Next ❯

Citations

Dec 28, 2016·The British Journal of Nutrition·Javier Ávila-RománVirginia Motilva
Mar 2, 2018·Antioxidants·Shaneice K Nettleford, K Sandeep Prabhu
Aug 24, 2018·Expert Review of Gastroenterology & Hepatology·Mohammad Hosein FarzaeiNima Rezaei
Jun 4, 2019·Journal of Neuroinflammation·Mahasweta DasSubhra Mohapatra
Jun 21, 2018·Journal of Cellular Biochemistry·D Sathya Prabhu, V Devi Rajeswari
Feb 26, 2019·Mediators of Inflammation·Longgui NingGuoqiang Xu
Oct 25, 2020·Biological Trace Element Research·Mostafa Vaghari-TabariAmir Ghorbanihaghjo
Jan 28, 2021·International Journal of Molecular Sciences·Giulia CaioniElisabetta Benedetti
Nov 5, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ji Yun HerEunok Im
Feb 7, 2020·European Journal of Pharmacology·Tarcisio Vieira de BritoAndré Luiz Dos Reis Barbosa
Aug 17, 2021·Investigative Ophthalmology & Visual Science·Jinghua BuWei Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here