Abstract
Photodynamic therapy (PDT) uses a combination of photosensitizers with visible light to generate reactive species and selectively kill tumor or unwanted tissue. Znln2S4 nanoparticles are widely implemented in photovoltaic device materials and photolysis water catalysts owing to their unique photoelectric properties. Whether Znln2S4 itself can be used as an effective dye in PDT is still unknown. To determine the effects and potential mechanism of Znln2S4PDT on HepG2 cell apoptosis, electron microscopic analysis was performed to monitor the apoptotic morphology of HepG2 cells upon exposure to Znln2S4-PDT. Flow cytometry was performed to measure the apoptosis rate and intracellular ROS production. Western blot and ELISA were performed to reveal the expression changes in Bax, caspase-3 and caspase-9. Data from this work suggested that cells exhibited the typical apoptotic morphology in response to Znln2S4-PDT, with high apoptotic rate. The intracellular ROS production after Znln2S4-PDT occurred in a dose-dependent manner. Moreover, Znln2S4-PDT augmented the expression levels of pro-apoptosis factors, especially, Bax, caspase-3 and caspase-9. Taken together, our novel findings, Znln2S4-PDT elicited HepG2 cell apoptosis, suggesting Z...Continue Reading
References
Jul 19, 2008·The FEBS Journal·Hiromichi Yonekawa, Yoshiko Akita
May 12, 2009·FEBS Letters·Xianwang WangWei R Chen
Dec 18, 2013·Future Oncology·Ron R Allison
Feb 20, 2014·ACS Applied Materials & Interfaces·Lin YeZhaohui Li
Aug 26, 2014·Nature Genetics·Yi-Bo GaoJie He
Aug 27, 2014·International Journal of Molecular Sciences·Anton ValkovMarina Nisnevitch
Dec 23, 2014·Future Medicinal Chemistry·Dennis K P Ng
Jan 7, 2015·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·David Kessel
Feb 25, 2015·Biological Trace Element Research·Xiaoyan YanGuohua Song
Mar 7, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Sai YangZilong Xia
Mar 21, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xianwang WangChengbiao Lu
Apr 25, 2015·Spine·Helen E GruberEdward N Hanley
May 9, 2015·International Journal of Molecular Sciences·Ivan Mfouo-Tynga, Heidi Abrahamse
Jun 30, 2015·Photochemistry and Photobiology·Eleftherios K PefkianakisGeorgios C Vougioukalakis
Oct 13, 2015·Chemical Communications : Chem Comm·Fenfen ShiDeli Jiang
Nov 10, 2015·Future Oncology·Maria Concetta Fargnoli, Ketty Peris
Feb 4, 2016·Cancer Research·Hirofumi FujitaHideyo Ohuchi
Jun 9, 2016·Journal of Hazardous Materials·Pengxiang QiuXianchuan Xie
Jul 30, 2016·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Matías E RodríguezViviana A Rivarola
Feb 2, 2017·Nature Communications·Min-Quan YangGhim Wei Ho
May 16, 2018·Proceedings of the National Academy of Sciences of the United States of America·Zhixuan ZhouPeter J Stang
Jul 20, 2018·Nature Communications·Rui GaoMin Wei
Aug 11, 2018·Biomaterials·Hairong WangZhuang Liu
Sep 16, 2018·Biomaterials·Shuang-Shuang WanXian-Zheng Zhang
Jan 1, 2019·Journal of Biomedical Nanotechnology·Changwei JiHongqian Guo