A novel pleural-bladder pump for the management of recurrent malignant pleural effusions: a feasibility animal study.

Respiratory Research
S LaroumagneP Astoul

Abstract

Recurrent malignant pleural effusions (MPE) are common and associated with significant morbidity in cancer patients. A new pump connecting the pleural cavity and the bladder may have application for the management of recurrent MPE. In a pre-clinical study, we investigated the utility of this pump in healthy pigs. A novel pump system (Pleurapump® system) was inserted into four pigs under general anaesthesia. A tunnelled-pleural catheter was connected to a subcutaneously implanted pump while the urinary bladder was connected by percutaneous technique. Animals were ventilated mechanically and pump functioning was tested using a range of ventilation parameters and spontaneous breathing. Fluid was added to the pleural space to mimic pleural effusion and to assess the effectiveness of the pump at removing fluid to the bladder. The 'pleurapump' system successfully transported fluid from the pleural cavity to the bladder. Pressure variations caused by respiration and variations in the amount of fluid in the pleural cavity had no impact on the pumping. Pumping stopped when the pleural cavity was drained. This pump can be implanted into pigs and successfully removed fluid from the pleural cavity to the bladder and may represent a new tre...Continue Reading

References

Aug 28, 2010·Thorax·Mark E RobertsUNKNOWN BTS Pleural Disease Guideline Group
Jun 2, 2012·American Journal of Respiratory and Critical Care Medicine·Georgios T Stathopoulos, Ioannis Kalomenidis
Nov 17, 2012·Respiration; International Review of Thoracic Diseases·Natasha F SaburAlain Tremblay
May 16, 2013·Current Opinion in Pulmonary Medicine·Helen E Davies, Y C Gary Lee
Sep 3, 2013·Clinics in Chest Medicine·Justin M Thomas, Ali I Musani
Dec 3, 2014·Seminars in Respiratory and Critical Care Medicine·Joseph H SkalskiFabien Maldonado
Jul 29, 2018·The European Respiratory Journal·Anna C BibbyNick A Maskell

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