A novel polymorphism of the CYP4A11 gene is associated with coronary artery disease

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Zhenyan FuNaoyuki Sato

Abstract

CYP4A11 (cytochrome P450, family 4, subfamily A, polypeptide 11) converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which plays a crucial role in the modulation of cardiovascular homeostasis. The aim of the present study was to assess the association between the human CYP4A11 gene and coronary artery disease (CAD). A total of 361 patients with CAD and 315 controls were genotyped for 4 single-nucleotide polymorphisms (SNPs) of the human CYP4A11 gene (rs9332978, rs4660980, rs3890011, and rs1126742). The data were assessed for 3 groups: total participants, men, and women via case-control studies. For total participants and men, the distribution of SNP3 (rs3890011) genotypes showed a significant difference between CAD and control participants (P = .030 and P = .013, respectively), the distribution of the recessive model of SNP3 (GG vs CC + GC) was significantly higher in CAD patients than in control participants (P = .011 and P = .014, respectively), the significant difference was retained after adjustment for covariates (for total participants, 95% confidence interval [CI]: 1.137-2.423, P = .009; and for males, 95% CI: 1.173-3.013, P = .009). rs3890011 maybe a novel polymorphism of the CYP4A11 gene associated ...Continue Reading

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Citations

Jul 28, 2015·European Journal of Clinical Investigation·Guillermo GervasiniJuan José Cubero
May 17, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·John R ChevilletKai Wang
Jul 6, 2020·Cell Biochemistry and Biophysics·Changjiang ZhangHao Xia

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Methods Mentioned

BETA
Genotyping
Assay
PCR

Software Mentioned

SPSS

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