A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-β1

Endocrinology
Chen-Che Jeff HuangD Forrest

Abstract

The development of the adrenal cortex involves the formation and then subsequent regression of immature or fetal inner cell layers as the mature steroidogenic outer layers expand. However, controls over this remodeling, especially in the immature inner layer, are incompletely understood. Here we identify an inner cortical cell population that expresses thyroid hormone receptor-β1 (TRβ1), one of two receptor isoforms encoded by the Thrb gene. Using mice with a Thrb(b1) reporter allele that expresses lacZ instead of TRβ1, β-galactosidase was detected in the inner cortex from early stages. Expression peaked at juvenile ages in an inner zone that included cells expressing 20-α-hydroxysteroid dehydrogenase, a marker of the transient, so-called X-zone in mice. The β-galactosidase-positive zone displayed sexually dimorphic regression in males after approximately 4 weeks of age but persisted in females into adulthood in either nulliparous or parous states. T3 treatment promoted hypertrophy of inner cortical cells, induced some markers of mature cortical cells, and, in males, delayed the regression of the TRβ1-positive zone, suggesting that TRβ1 could partly divert the differentiation fate and counteract male-specific regression of inne...Continue Reading

References

Jul 1, 1992·The Journal of Clinical Investigation·S J SpencerR B Jaffe
Dec 18, 1986·Nature·C WeinbergerR M Evans
Jan 1, 1986·General and Comparative Endocrinology·C F DeaconI C Jones
Jan 1, 1968·Zeitschrift für Zellforschung und mikroskopische Anatomie·T Sato
Jun 1, 1972·The Journal of Clinical Endocrinology and Metabolism·T F GallagherD K Fukushima
Sep 1, 1984·The Journal of Endocrinology·J G Shire, W G Beamer
Jun 1, 1993·Endocrine Reviews·S RefetoffS J Usala
Jun 1, 1997·Endocrine Reviews·S Mesiano, R B Jaffe
Dec 8, 1998·Nature Genetics·R N YuJ L Jameson
Aug 3, 1999·The Journal of Clinical Investigation·E D AbelF Wondisford
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·A Campos-BarrosD Forrest
Feb 25, 2000·Neuroscience Letters·N Hadj-SahraouiB Demeneix
Mar 10, 2004·The Journal of Reproduction and Development·Atsushi Tohei
Jul 5, 2005·European Journal of Endocrinology·Elizabeth O JohnsonGeorge P Chrousos
Sep 24, 2008·Molecular and Cellular Biology·Mohamad ZubairKen-ichirou Morohashi
May 1, 2009·Endocrine Reviews·Alex C KimGary D Hammer
Dec 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Peter KingEd Laufer
Feb 2, 2010·Endocrinology·Chen-Che Jeff HuangHumphrey Hung-Chang Yao
Mar 20, 2010·Apoptosis : an International Journal on Programmed Cell Death·Atsuko Ishizuya-OkaYun-Bo Shi
Jun 16, 2010·PLoS Genetics·Isabelle Sahut-BarnolaAntoine Martinez
Jul 8, 2011·Endocrinology·Joshua O ScheysGary D Hammer
Mar 1, 2012·Journal of Feline Medicine and Surgery·Sabine RamspottAstrid Wehner
Aug 15, 2012·Biochimica Et Biophysica Acta·Maria SirakovMichelina Plateroti
Mar 27, 2013·Nature Reviews. Endocrinology·Lily NgDouglas Forrest
May 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Alies A van MullemRobin P Peeters
Aug 14, 2013·The Journal of Clinical Endocrinology and Metabolism·Carla MoranKrishna Chatterjee
Sep 17, 2013·Developmental Cell·Bethany D FreedmanDavid T Breault

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Citations

Feb 6, 2016·Paediatric and Perinatal Epidemiology·Jason A WilkenGayle C Windham
Feb 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Sofia GalanouAntonis Voutetakis
May 16, 2015·Endocrinology·Fredric E Wondisford
Mar 4, 2020·Thyroid : Official Journal of the American Thyroid Association·Svetlana MinakhinaFredric E Wondisford
Mar 8, 2021·Molecular and Cellular Endocrinology·Typhanie Dumontet, Antoine Martinez
Sep 8, 2021·Italian Journal of Pediatrics·Francesco BaldoGianluca Tornese

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