A novel population of progenitor cells expressing cannabinoid receptors in the subependymal layer of the adult normal and Huntington's disease human brain

Journal of Chemical Neuroanatomy
M A CurtisM Glass

Abstract

Progenitor cells in the adult human brain subependymal layer are capable of producing new neurons and glial cells that may be useful as a source of cells for endogenous cell replacement for regions of the brain that undergo degeneration due to a neurodegenerative disease such as Huntington's disease, Parkinson's disease or Alzheimer's disease. We have previously demonstrated that in the human Huntington's disease brain there are increased numbers of progenitor cells proportional to the severity of the gene defect responsible for the disease and proportional to the severity of the pathology of the disease. One of the criticisms of a potential endogenous progenitor cell replacement therapy has been that the endogenous progenitor cells also contain the Huntington's disease gene and would therefore be just as susceptible to degeneration as those in the degenerate brain region. In the present study we have demonstrated the presence of cannabinoid CB1 receptors, which are preferentially lost in Huntington's disease, colocalised with the proliferative marker PCNA in the adult normal and Huntington's disease subependymal layer. This population of CB1 positive cells only colabels with PCNA and not with neuronal, glial, microglial or oli...Continue Reading

References

Jul 15, 1999·The Journal of Comparative Neurology·E H Van Vulpen, D Van Der Kooy
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·J FallonS Loughlin
Apr 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·S YoshimuraM A Moskowitz
Aug 6, 2002·Nature Medicine·Andreas ArvidssonOlle Lindvall
Nov 26, 2002·Annals of Neurology·Jack M ParentDonna M Ferriero
May 16, 2003·Journal of Neuroscience Research·Paola TirassaLuigi Aloe
Aug 26, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jack M Parent
Dec 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Johan AarumMats A A Persson
Jul 22, 2004·Molecular Pharmacology·Kunlin JinDavid A Greenberg

❮ Previous
Next ❯

Citations

Jul 10, 2009·European Archives of Psychiatry and Clinical Neuroscience·Ismael Galve-RoperhManuel Guzmán
Aug 21, 2007·Nature Reviews. Neuroscience·Maurice A CurtisPeter S Eriksson
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos
Apr 5, 2008·Neurological Research·J Louro, D D Pearse
Dec 17, 2008·Journal of Bodywork and Movement Therapies·John M McPartland
Jun 14, 2017·Journal of Neurochemistry·Balapal S BasavarajappaShivakumar Subbanna
Apr 4, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ismael Galve-RoperhManuel Guzmán
Aug 17, 2010·Pharmaceuticals·Sebastian Walther, Michael Halpern
Apr 5, 2007·Nature Protocols·Henry J WaldvogelRichard L M Faull
Nov 10, 2007·Neuropathology and Applied Neurobiology·J E SimpsonUNKNOWN MRC Cognitive Function and Ageing Neuropathology Study Group
Feb 18, 2009·British Journal of Pharmacology·Javier Fernández-Ruiz
Jun 10, 2010·The Journal of Comparative Neurology·Juan SuárezP Fernández-Llebrez
Jul 27, 2010·Journal of Cellular Physiology·Henrik Landgren, Maurice A Curtis
Jul 5, 2016·Journal of Central Nervous System Disease·He Liu, Ni Song

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
M A CurtisR L M Faull
Proceedings of the National Academy of Sciences of the United States of America
K JinD A Greenberg
Proceedings of the National Academy of Sciences of the United States of America
K JinD A Greenberg
Proceedings of the National Academy of Sciences of the United States of America
K JinD A Greenberg
© 2021 Meta ULC. All rights reserved