A novel, population-specific approach to define frailty.

Age
Alberto MontesantoGiuseppe Passarino

Abstract

The description of frailty, a syndrome of the elderly due to the decline of homeostatic capacities, has opened new opportunities in the study of the biological basis of human aging. However, the noticeable heterogeneity for this trait in different geographic areas makes it difficult to use standardized methods for measuring the quality of aging in different populations. Consequently, the necessity to carry out population-specific surveys to define tools which are able to highlight groups of subjects with homogeneous aging phenotype within each population has emerged. We carried out an extensive monitoring of the status of the elderly population in Calabria, southern Italy, performing a geriatric multidimensional evaluation of 680 subjects (age range 65-108 years). Then, in order to classify the subjects, we applied a cluster analysis which considered physical, cognitive, and psychological parameters such as classification variables. We identified groups of subjects homogeneous for the aging phenotypes. The diagnostic and predictive soundness of our classification was confirmed by a 3-year longitudinal study. In fact, both Kaplan-Meier estimates of the survival functions and Cox proportional hazard models indicate higher surviva...Continue Reading

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Citations

Jul 16, 2013·Biogerontology·Suresh I S Rattan
Feb 22, 2011·Age·Dina BellizziGiuseppe Passarino
Nov 22, 2011·Journal of Nutrition in Gerontology and Geriatrics·Roschelle A Heuberger
Mar 19, 2013·Rejuvenation Research·Maurizio BerardelliGiuseppe Passarino
Aug 31, 2014·Experimental Gerontology·Paola GueresiEmanuela Gualdi Russo
Apr 25, 2012·Immunity & Ageing : I & a·Alberto MontesantoGiuseppe Passarino
Nov 18, 2011·The Journal of Nutrition, Health & Aging·J MuleroA Martinez-Cacha
Sep 8, 2015·Epigenomics·Patrizia D'AquilaDina Bellizzi
Apr 5, 2016·Biogerontology·Walter LuytenSuresh I S Rattan
Apr 25, 2012·Experimental Gerontology·Dino Demirovic, Suresh I S Rattan
Jul 24, 2014·São Paulo Medical Journal = Revista Paulista De Medicina·André FattoriMaria Elena Guariento
Nov 14, 2019·Current Pharmaceutical Design·Francesco GuarasciGiuseppe Passarino
Oct 2, 2020·International Journal of Molecular Sciences·Marta DossenaAnnibale Alessandro Puca
Mar 7, 2021·International Journal of Environmental Research and Public Health·José Luis García-GiménezFederico V Pallardó
May 4, 2017·Mechanisms of Ageing and Development·Alberto MontesantoGiuseppe Passarino

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