A novel potential role of pituitary gonadotropins in the pathogenesis of human colorectal cancer

PloS One
Wojciech MarliczMariusz Z Ratajczak

Abstract

Colorectal cancer (CRC) is a leading cause of death in the western world, and its incidence increases with patient age. It is also known that with age there occur changes in the levels of certain hormones, including an increase in the secretion of pituitary gonadotropins (PtGs) as a result of the loss of gonadal hormone feedback. We recently reported that functional PtG receptors are expressed in human lung cancer cells, rhabdomyosarcoma cells, and malignant hematopoietic stem cells. Here we report for the first time that the receptors for follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are expressed in primary tumor samples isolated from CRC patients as well as in the established human CRC cell lines HTC116 and HTB37. Moreover, we also report that PtGs stimulate chemotaxis, adhesion, and proliferation of these cell lines. Our results suggest that PtGs play an important and underappreciated role in CRC pathogenesis, and we call for further studies to better define their role in gastrointestinal malignancies and their direct effect on putative CRC cancer stem cells.

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Citations

Dec 14, 2018·Journal of Clinical Medicine·Karolina Skonieczna-ŻydeckaIgor Łoniewski
Apr 27, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Błażej MisiakJerzy Samochowiec

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Methods Mentioned

BETA
biopsies
flow cytometry
PCR
hormone replacement therapy

Software Mentioned

- Blast
Primer

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