A Novel Prediction Model for Significant Liver Fibrosis in Patients with Chronic Hepatitis B.

BioMed Research International
Yaqiong ChenBo Hu

Abstract

Preventing liver fibrosis from progressing to cirrhosis and even liver cancer is a key step in the treatment of chronic hepatitis B (CHB). This study is aimed at constructing and validating a new nomogram for predicting significant liver fibrosis (S ≥ 2) in CHB patients. The nomogram was based on a retrospective study of 252 CHB patients. The predictive accuracy and discriminative ability of the nomogram were evaluated by the area under receiver operating characteristic curve (AUROC), decision curves, and calibration curve compared with the fibrosis 4 score (FIB-4) and aspartate aminotransferase-to-platelet ratio index (APRI). The results were validated using bootstrap resampling and an external set of 168 CHB patients. A total of 420 CHB patients were enrolled based on liver biopsy results. Independent factors predicting significant liver fibrosis were laminin (LN), procollagen type III N-terminal peptide (PIIINP), and blood platelet count (PLT) in a multivariate analysis, and these factors were selected to construct the nomogram. The calibration curve for the probability of significant liver fibrosis showed optimal agreement between the prediction from the nomogram and actual observation. The prediction from the nomogram was ...Continue Reading

References

Oct 19, 2002·The American Journal of Gastroenterology·Arie RegevEugene R Schiff
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
Oct 8, 2004·The New England Journal of Medicine·Yun-Fan LiawUNKNOWN Cirrhosis Asian Lamivudine Multicentre Study Group
Jul 26, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cora N Sternberg
Jun 15, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anaïs Vallet-PichardStanislas Pol
Apr 7, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Leonard B SeeffUNKNOWN HALT–C Trial Group
Jul 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Indra Neil GuhaJayant A Talwalkar
Aug 2, 2011·The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology·Gülseren SevenDetlef Schuppan
Jan 30, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yizhou WangFeng Shen
Sep 13, 2013·Annals of Internal Medicine·Roger Chou, Ngoc Wasson
Nov 16, 2014·Gut·Xiaolong QiChangqing Yang
Dec 11, 2014·World Journal of Gastroenterology : WJG·Suraj SharmaGeoffrey Christopher Nguyen
Jan 27, 2016·BMJ : British Medical Journal·Andrew J VickersEwout W Steyerberg
Aug 3, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xingshun QiXiaozhong Guo
Aug 23, 2016·World Journal of Gastroenterology : WJG·Da-Wu ZengYue-Yong Zhu
May 26, 2017·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Chang Seok BangIl Han Song
Jul 10, 2018·Open Access Macedonian Journal of Medical Sciences·Marija DimzovaNikola Orovcanec

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

rpart
R
SPSS
FibroScan

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