A novel predictive model for poor in-hospital outcomes in patients with acute kidney injury after cardiac surgery.

The Journal of Thoracic and Cardiovascular Surgery
Zhongli ChenLiang Chen

Abstract

Patients with cardiac surgery-associated acute kidney injury are at risk of renal replacement therapy and in-hospital death. We aimed to develop and validate a novel predictive model for poor in-hospital outcomes among patients with cardiac surgery-associated acute kidney injury. A total of 196 patients diagnosed with cardiac surgery-associated acute kidney injury were enrolled in this study as the training cohort, and 32 blood cytokines were measured. Least absolute shrinkage and selection operator regression and random forest quantile-classifier were performed to identify the key blood predictors for in-hospital composite outcomes (requiring renal replacement therapy or in-hospital death). The logistic regression model incorporating the selected predictors was validated internally using bootstrapping and externally in an independent cohort (n = 52). A change in serum creatinine (delta serum creatinine) and interleukin 16 and interleukin 8 were selected as key predictors for composite outcomes. The logistic regression model incorporating interleukin 16, interleukin 8, and delta serum creatinine yielded the optimal performance, with decent discrimination (area under the receiver operating characteristic curve: 0.947; area under...Continue Reading

References

Sep 28, 2002·Critical Care Medicine·Philipp G H MetnitzWilfred Druml
Nov 25, 2003·Journal of Chemical Information and Computer Sciences·Vladimir SvetnikBradley P Feuston
Mar 3, 2007·Critical Care : the Official Journal of the Critical Care Forum·Ravindra L MehtaUNKNOWN Acute Kidney Injury Network
Jul 17, 2007·BMC Medical Research Methodology·Martijn W HeymansHenrica C W de Vet
Nov 16, 2007·Kidney International·S WangC Du
Aug 13, 2009·Nephron. Clinical Practice·Orfeas LiangosBertrand L Jaber
Nov 23, 2010·Nature Reviews. Immunology·Grace Y Chen, Gabriel Nuñez
Sep 6, 2013·Kidney International·John M ArthurUNKNOWN SAKInet Investigators
Jan 28, 2015·JAMA : the Journal of the American Medical Association·Mark FitzgeraldRoger J Lewis
Apr 10, 2015·Journal of the American Society of Nephrology : JASN·William R ZhangUNKNOWN TRIBE-AKI Consortium
Sep 5, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Jennie LinF Perry Wilson
Nov 13, 2015·Journal of the American Society of Nephrology : JASN·Hamid RabbUNKNOWN Acute Dialysis Quality Initiative Consensus XIII Work Group
Jan 24, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Martin Hermann BernardiAndrea Lassnigg
Apr 18, 2016·Seminars in Nephrology·Shrikant R MulayHans-Joachim Anders
Jul 5, 2016·Critical Care : the Official Journal of the Critical Care Forum·Jason B O'NealFrederic T Billings
Jul 23, 2016·Journal of the American Society of Nephrology : JASN·Lucile AmroucheDany Anglicheau
Nov 8, 2016·Current Opinion in Anaesthesiology·Dana Y Fuhrman, John A Kellum
Nov 15, 2016·Current Opinion in Anaesthesiology·Nicholas LysakCharles Hobson
Feb 23, 2017·The Annals of Thoracic Surgery·Dennis G MoledinaUNKNOWN Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury (TRIBE-AKI) Consortium
Jul 2, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Jason H Greenberg, Chirag R Parikh
Aug 20, 2017·The Annals of Thoracic Surgery·Christina A de FontnouvelleUNKNOWN TRIBE-AKI Consortium
Sep 5, 2017·Nature Reviews. Nephrology·Ying Wang, Rinaldo Bellomo
Feb 16, 2019·Pattern Recognition·Robert O'Brien, Hemant Ishwaran
Oct 15, 2020·The Journal of Thoracic and Cardiovascular Surgery·Hemant Ishwaran, Eugene H Blackstone
Jan 13, 2021·The Journal of Thoracic and Cardiovascular Surgery·Angela L LangAndra E Duncan

❮ Previous
Next ❯

Citations

Jun 2, 2021·The Journal of Thoracic and Cardiovascular Surgery·Thomas Vierhout, Meghana R K Helder
May 30, 2021·The Journal of Thoracic and Cardiovascular Surgery·William L HolmanJames E Davies

❮ Previous
Next ❯

Related Concepts

Related Feeds

Related Papers

The International Journal of Artificial Organs
Claudio RoncoRinaldo Bellomo
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Joshua J BlinderMichael A Ferguson
Journal of the American College of Cardiology
Peter A McCulloughHarold Szerlip
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Ya-Yang LiuGui-Zhen Yang
© 2021 Meta ULC. All rights reserved