PMID: 22329201Feb 15, 2012Paper

A novel prosurvival model for cancer under environmental challenge: the "heart-felt" message for therapeutic intervention

Oncology Research
John A Loudon

Abstract

In the present review I propose a novel model system to analyze and to aid prediction of suitable targeted treatments aimed at therapy-resistant cancer cells. The concept of cancer cell prosurvival reaction to adverse external tumor microenvironment is explored in the context of the reaction of myocardium to unfavorable physiologic conditions. Many of the protective and indeed nonprotective (tumor suppressor) reactive mechanisms in both cancer and heart tissue challenged with an adverse environment follow similar and predictable patterns. Based on these observations, a model is constructed that may aid prediction of future therapies aimed to target cancer--particularly chemotherapy/radiotherapy resistance and dormant disease. As another feature of the model, ways to better forecast future therapies aimed at augmenting cardioprotective paths is made possible through understanding of pathways used to sustain cancer cells under external challenges.

Citations

Jan 8, 2013·Cardiovascular Drugs and Therapy·John A Loudon
Feb 12, 2013·Cardiovascular Drugs and Therapy·John A Loudon
Nov 28, 2013·Cardiovascular Drugs and Therapy·John A Loudon
Mar 9, 2013·British Dental Journal·J Loudon

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