A novel protein kinase-like domain in a selenoprotein, widespread in the tree of life.

PloS One
Małgorzata DudkiewiczKrzysztof Pawłowski

Abstract

Selenoproteins serve important functions in many organisms, usually providing essential oxidoreductase enzymatic activity, often for defense against toxic xenobiotic substances. Most eukaryotic genomes possess a small number of these proteins, usually not more than 20. Selenoproteins belong to various structural classes, often related to oxidoreductase function, yet a few of them are completely uncharacterised.Here, the structural and functional prediction for the uncharacterised selenoprotein O (SELO) is presented. Using bioinformatics tools, we predict that SELO protein adopts a three-dimensional fold similar to protein kinases. Furthermore, we argue that despite the lack of conservation of the "classic" catalytic aspartate residue of the archetypical His-Arg-Asp motif, SELO kinases might have retained catalytic phosphotransferase activity, albeit with an atypical active site. Lastly, the role of the selenocysteine residue is considered and the possibility of an oxidoreductase-regulated kinase function for SELO is discussed.The novel kinase prediction is discussed in the context of functional data on SELO orthologues in model organisms, FMP40 a.k.a.YPL222W (yeast), and ydiU (bacteria). Expression data from bacteria and yeast ...Continue Reading

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Citations

Apr 2, 2013·Biochimica Et Biophysica Acta·Anna Lenart, Krzysztof Pawłowski
Mar 22, 2014·Future Medicinal Chemistry·Sandra W Cowan-JacobStefan Knapp
Oct 16, 2012·Nucleic Acids Research·Valérie CognatLaurence Maréchal-Drouard
Jul 30, 2014·Free Radical Biology & Medicine·S PenglaseS Ellingsen
Jul 11, 2013·PloS One·Małgorzata DudkiewiczKrzysztof Pawłowski
Nov 5, 2013·Metallomics : Integrated Biometal Science·Marco RomanCarlo Barbante
Jul 18, 2019·Proceedings of the National Academy of Sciences of the United States of America·Mitchell L LopezNatalia Jura
Jul 6, 2014·Physiological Reviews·Vyacheslav M LabunskyyVadim N Gladyshev
Jul 18, 2020·Biochemical Society Transactions·Marcin GradowskiKrzysztof Pawłowski
Jun 11, 2020·The Journal of Biological Chemistry· NitikaMatthias C Truttmann
Jul 19, 2016·Cell Biology International·Jidong YanShemin Lu
May 21, 2019·PeerJ·Małgorzata Dudkiewicz, Krzysztof Pawłowski
Jun 18, 2017·Biochemical Society Transactions·Annette V Jacobsen, James M Murphy
Jan 22, 2021·Proceedings of the National Academy of Sciences of the United States of America·Heiko SlaninaJohn Ziebuhr
Dec 9, 2020·Biochemical and Biophysical Research Communications·Zhenming JinHaitao Yang
Oct 3, 2018·Cell·Anju SreelathaVincent S Tagliabracci
Apr 16, 2021·PeerJ·Zbigniew WyżewskiKrzysztof Pawłowski
Nov 18, 2021·Animal Science Journal = Nihon Chikusan Gakkaihō·Monika MichalczukPaweł Konieczka

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Methods Mentioned

BETA
Phosphotransferase

Software Mentioned

Kinase Knowledgebase
MicrobesOnline
BLAST
MultiLoc
FFAS03
HHsenser
SOPMA
MODELLER
Symatlas
MUSCLE

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