A Novel Public MR Image Dataset of Multiple Sclerosis Patients With Lesion Segmentations Based on Multi-rater Consensus

Neuroinformatics
Žiga LesjakŽiga Špiclin

Abstract

Quantified volume and count of white-matter lesions based on magnetic resonance (MR) images are important biomarkers in several neurodegenerative diseases. For a routine extraction of these biomarkers an accurate and reliable automated lesion segmentation is required. To objectively and reliably determine a standard automated method, however, creation of standard validation datasets is of extremely high importance. Ideally, these datasets should be publicly available in conjunction with standardized evaluation methodology to enable objective validation of novel and existing methods. For validation purposes, we present a novel MR dataset of 30 multiple sclerosis patients and a novel protocol for creating reference white-matter lesion segmentations based on multi-rater consensus. On these datasets three expert raters individually segmented white-matter lesions, using in-house developed semi-automated lesion contouring tools. Later, the raters revised the segmentations in several joint sessions to reach a consensus on segmentation of lesions. To evaluate the variability, and as quality assurance, the protocol was executed twice on the same MR images, with a six months break. The obtained intra-consensus variability was substantial...Continue Reading

References

Feb 15, 2003·IEEE Transactions on Medical Imaging·Alex P ZijdenbosAlan C Evans
Mar 10, 2004·NeuroImage·Petronella AnbeekJeroen van der Grond
Jul 15, 2004·IEEE Transactions on Medical Imaging·Simon K WarfieldWilliam M Wells
Jan 1, 1994·IEEE Transactions on Medical Imaging·A P ZijdenbosA C Palmer
Mar 11, 2009·IEEE Transactions on Medical Imaging·Olivier Commowick, Simon K Warfield
Nov 20, 2009·IEEE Transactions on Medical Imaging·Stefan KleinJosien P W Pluim
Apr 10, 2010·IEEE Transactions on Medical Imaging·Nicholas J TustisonJames C Gee
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Sep 2, 2011·IEEE Transactions on Medical Imaging·Juan Eugenio IglesiasZhuowen Tu
Mar 26, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Veronica PopescuUNKNOWN MAGNIMS Study Group
Dec 19, 2013·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·M PatzigG Fesl
Jun 22, 2014·IEEE Transactions on Medical Imaging·Alireza Akhondi-AslSimon K Warfield
Jan 15, 2015·Therapeutic Advances in Neurological Disorders·Martin StangelBernd C Kieseier
Apr 17, 2015·IEEE Transactions on Medical Imaging·M Jorge CardosoSebastien Ourselin

❮ Previous
Next ❯

Citations

Jul 16, 2019·NPJ Digital Medicine·Baris KanberOlga Ciccarelli
Nov 15, 2017·Journal of Medical Imaging·Alfiia GalimzianovaŽiga Špiclin
Nov 4, 2020·Interdisciplinary Sciences, Computational Life Sciences·Wenhao JiangSilun Wang
Dec 18, 2019·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Muhammad Febrian RachmadiTaku Komura
Jan 18, 2021·Medical Image Analysis·Christoph BaurShadi Albarqouni

❮ Previous
Next ❯

Software Mentioned

BrainSeg3D
Seg3D

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.