Abstract
Vaccination alone is not sufficiently effective to protect human from post-exposure rabies virus infection due to delayed generation of rabies virus neutralizing antibodies and weak cellular immunity. Therefore, it is vital to develop safer and more efficacious vaccine against rabies. PIKA, a stabilized chemical analog of double-stranded RNA that interacts with TLR3, was employed as adjuvant of rabies vaccine. The efficacy and safety of PIKA rabies vaccine were evaluated. The results showed that PIKA rabies vaccine enhanced both humoral and cellular immunity. After viral challenge, PIKA rabies vaccine protected 70-80% of animals, while the survival rate of non-adjuvant vaccine group (control) was 20-30%. According to the results of toxicity tests, PIKA and PIKA rabies vaccine are shown to be well tolerated in mice. Thus, this study indicates that PIKA rabies vaccine is an effective and safe vaccine which has the potential to develop next-generation rabies vaccine and encourage the start of clinical studies.
References
Aug 1, 1990·Vaccine·R Jayakumar, P Ramadass
Jan 1, 1993·Archives of Virology·H X LinP Perrin
Jun 1, 1994·Clinical Immunology and Immunopathology·O ThraenhartB Dietzschold
Jul 22, 1998·Journal of Immunological Methods·F CliquetL Sagné
Jan 18, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Henry WildeVisith Sitprija
Jul 30, 2002·The Lancet Infectious Diseases·Charles E RupprechtThiravat Hemachudha
Jan 20, 2009·Vaccine·Yuk-Fai LauEng-Eong Ooi
Jul 30, 2010·Virology·Yuk-Fai LauKanta Subbarao
Mar 25, 2011·Environmental Health and Preventive Medicine·Yu-e SongCai-yan Cui
Apr 7, 2011·Virologica Sinica·Wei-wei GaiHui-min Yan
Mar 22, 2012·Vaccine·A ManceboD Fuentes
Dec 12, 2012·Archives of Virology·Ping ZhangXi Huang
Jul 16, 2013·Current Opinion in Virology·Suzanne P M WeltenRamon Arens
May 23, 2014·Annals of the New York Academy of Sciences·Jing Wang, Hisashi Arase
Jul 22, 2014·Trends in Immunology·Nicole L La Gruta, Stephen J Turner
Aug 16, 2014·Journal of Immunology Research·Anabelle VisperasBooki Min
Aug 19, 2014·Vaccine·Lay Hoon TangYuk Fai Lau
Jan 2, 2015·Journal of Virology·Ying HuangBiao He
Citations
Apr 14, 2016·Virologica Sinica·Yange NiuWenjun Liu
Oct 28, 2016·Antiviral Research·Yi ZhangYuan Liu
Jan 26, 2017·Vaccine·Limin WijayaJenny G Low
Mar 31, 2018·Human Vaccines & Immunotherapeutics·Zhuofan LiGuoyang Liao
Dec 23, 2017·Human Vaccines & Immunotherapeutics·Cunbao LiuYanbing Ma
Jun 4, 2018·Pathogens and Disease·Songyuan YaoMingkai Xu
Sep 27, 2018·International Journal of Veterinary Science and Medicine·A El-Sayed
Dec 11, 2019·Viruses·Chen ChenLing Zhao
Jul 4, 2017·Tropical Medicine and Infectious Disease·Aurore LebrunD Craig Hooper
Jun 23, 2019·Vaccines·Hildegund C J Ertl
Sep 25, 2019·Human Vaccines & Immunotherapeutics·Mark A MatsonGarrett E Bergman
Apr 4, 2021·Vaccines·Jiao TongDapeng Zhou
May 25, 2021·Microbial Pathogenesis·Firouzeh FarahtajAmir Ghaemi
Jul 6, 2021·Clinical and Experimental Vaccine Research·Iman Ibrahim NegmAly Fahmy Mohamed
Aug 28, 2020·Journal of Medicinal Chemistry·Stefano FedericoNicola Relitti
Sep 2, 2021·PloS One·Pan Kyeom KimSoo Young Lee
Sep 9, 2021·Journal of Virology·Zongmei WangLing Zhao