A novel radioligand for imaging the AT1 angiotensin receptor with PET

Nuclear Medicine and Biology
William B MathewsZ Szabo

Abstract

2-Butyl-5-methoxymethyl-6-(1-oxopyridin-2-yl)-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-3H-imidazo[4,5-b]pyridine (KR31173) was radiolabeled by coupling a tetrazole-protected hydroxy precursor with [(11)C] methyl iodide and removing the protecting group by acid hydrolysis. In mice, the highest uptake of [(11)C] KR31173 was in the adrenal glands, kidneys, and liver. Tissue to blood ratios were generally greater than 10:1. Uptake of the tracer in the adrenal glands, kidneys, lungs, and heart was blocked with a 1 mg/kg dose of KR31173 or MK-996.

References

May 1, 1991·Annals of Emergency Medicine·J R Roberts, R C Wuerz
Apr 11, 1991·American Journal of Hypertension·P C WongP B Timmermans
Jul 18, 1987·British Medical Journal·A J WinningA Guz
Jun 13, 1987·British Medical Journal·D M Coulter, I R Edwards
Dec 8, 1988·The New England Journal of Medicine·G H Williams
Dec 1, 1994·European Heart Journal·P B Timmermans, R D Smith
Dec 1, 1994·European Heart Journal·M de GasparoP Erne
Feb 1, 1996·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·T G HamillE M Naylor
Jun 26, 2001·Journal of the American Society of Nephrology : JASN·Zsolt SzaboKathryn Sandberg

❮ Previous
Next ❯

Citations

Mar 18, 2006·Nephron. Clinical Practice·Sabine E HaufeU Haberkorn
Mar 4, 2014·Current Cardiology Reports·Jamshid Shirani, Vasken Dilsizian
Dec 22, 2007·Seminars in Nuclear Medicine·Zsolt SzaboWilliam B Mathews
Feb 7, 2006·Nuclear Medicine and Biology·Tamas G ZoberZsolt Szabo
Dec 17, 2005·Seminars in Nuclear Medicine·Zsolt SzaboPhillip R Brown
Oct 2, 2013·BioMed Research International·Nedim C M GulaldiZsolt Szabo
Nov 20, 2012·Journal of the American College of Cardiology·Kenji FukushimaFrank M Bengel
Aug 3, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jamshid ShiraniVasken Dilsizian
Oct 1, 2015·Nuclear Medicine and Biology·Hiroki HashimotoMing-Rong Zhang
Dec 1, 2014·Neurobiology of Aging·Heidi I L JacobsPaul M Matthews
Nov 16, 2018·ChemMedChem·Matthias HoffmannMichael Decker
Jan 19, 2018·Basic Research in Cardiology·Daniel CurleyRené M Botnar
Sep 23, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jennifer L RogersSusan E Mulroney
Mar 14, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Nicholas R Ferreri
Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martha Sahylí Ortega PijeiraEmerson Soares Bernardes
Jun 13, 2009·Journal of Receptor and Signal Transduction Research·Alex N Eberle, Gabriele Mild
Nov 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Takahiro HiguchiFrank M Bengel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nuclear Medicine and Biology
Tamas G ZoberZ Szabo
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
C S PatlakJ D Fenstermacher
© 2022 Meta ULC. All rights reserved