PMID: 9650544Jul 3, 1998Paper

A novel recombinant soluble human thrombomodulin, ART-123, activates the protein C pathway in healthy male volunteers

Journal of Clinical Pharmacology
M NakashimaK Tsuruta

Abstract

The effect of a novel recombinant soluble human thrombomodulin, ART-123, on protein C activation was investigated by measuring plasma prothrombinase activity in four healthy male volunteers. ART-123 at a dose of 0.3 mg was administered as a bolus intravenous injection for 1 minute. Plasma ART-123 concentration and prothrombinase activity were determined before and immediately, 24, and 48 hours after injection, and thromboelastography was recorded before and immediately and 24 hours after injection. The mean elimination half-life was 19.82 +/- 2.10 hours. Compared with pretreatment levels, ART-123 reduced prothrombinase activity by 44.2 +/- 11.7%, 52.1 +/- 10.8%, and 61.0 +/- 14.7%, respectively, immediately, 24, and 48 hours after injection, suggesting that ART-123 activated the protein C pathway. ART-123 did not affect thromboelastography values. There were no abnormal findings for objective signs or laboratory tests, including blood pressure, heart rate, electrocardiogram, body temperature, hematology, coagulation and hemostatic parameters, blood chemistry, and urinalysis. Based on these observations, ART-123 at a dose of 0.3 mg can activate the protein C pathway in healthy volunteers.

References

Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R W JackmanR D Rosenberg
Nov 1, 1981·Journal of Pharmacobio-dynamics·K YamaokaT Uno

❮ Previous
Next ❯

Citations

Jul 19, 2002·Seminars in Hematology·Stephan Moll, Harold R Roberts
Mar 4, 2009·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K TsurutaT Kohira
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Satoshi Gando, Yasuhiro Otomo
Oct 1, 2004·Journal of Thrombosis and Haemostasis : JTH·S MollG C White
Apr 23, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Fiona A MartinPhilip M Cummins
Aug 1, 2013·Physiological Reviews·Kendra N IskanderDaniel G Remick
Sep 21, 2020·Drugs·Philippe VignonBruno François

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.