A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation

Circulation
Guoqing ZhuangBeiyan Zhou

Abstract

Macrophage activation plays a crucial role in regulating adipose tissue inflammation and is a major contributor to the pathogenesis of obesity-associated cardiovascular diseases. On various types of stimuli, macrophages respond with either classic (M1) or alternative (M2) activation. M1- and M2-mediated signaling pathways and corresponding cytokine production profiles are not completely understood. The discovery of microRNAs provides a new opportunity to understand this complicated but crucial network for macrophage activation and adipose tissue function. We have examined the activity of microRNA-223 (miR-223) and its role in controlling macrophage functions in adipose tissue inflammation and systemic insulin resistance. miR-223(-/-) mice on a high-fat diet exhibited an increased severity of systemic insulin resistance compared with wild-type mice that was accompanied by a marked increase in adipose tissue inflammation. The specific regulatory effects of miR-223 in myeloid cell-mediated regulation of adipose tissue inflammation and insulin resistance were then confirmed by transplantation analysis. Moreover, using bone marrow-derived macrophages, we demonstrated that miR-223 is a novel regulator of macrophage polarization, whic...Continue Reading

References

May 1, 1995·The Journal of Clinical Investigation·G S HotamisligilB M Spiegelman
Aug 2, 2001·Nature Medicine·A H BergP E Scherer
Dec 6, 2003·Science·Chang-Zheng ChenDavid P Bartel
Dec 31, 2003·Cell·Benjamin P LewisChristopher B Burge
Nov 4, 2004·American Journal of Physiology. Endocrinology and Metabolism·Morvarid KabirRichard N Bergman
Feb 3, 2005·Nature Medicine·Melek C ArkanMichael Karin
Apr 5, 2005·Nature Genetics·Azra KrekNikolaus Rajewsky
May 14, 2005·Circulation Research·Anders H Berg, Philipp E Scherer
Dec 13, 2005·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Jan 7, 2006·Nature Medicine·Benoit R Gauthier, Claes B Wollheim
Jan 4, 2007·The Journal of Clinical Investigation·Carey N LumengAlan R Saltiel
Apr 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Beiyan ZhouHarvey F Lodish
Jun 9, 2007·Circulation Research·Chien-Ping LiangAlan R Tall
Jul 7, 2007·Molecular Cell·Andrew GrimsonDavid P Bartel
Sep 8, 2007·The Journal of Clinical Investigation·Takashi NomiyamaDennis Bruemmer
Jan 22, 2008·Nature Reviews. Immunology·Harvey F LodishChang-Zheng Chen
Feb 19, 2008·Nature·Jonathan B JohnnidisFernando D Camargo
Nov 26, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Onpan CheungArun J Sanyal
Nov 26, 2009·Human Immunology·Valerio FulciGiuseppe Macino
May 15, 2010·Science·Katey J RaynerCarlos Fernández-Hernando

❮ Previous
Next ❯

Citations

Mar 19, 2013·Trends in Immunology·Mario Leonardo SquadritoMikael J Pittet
Feb 27, 2013·Nature Reviews. Nephrology·Walter H Hörl
Jun 19, 2013·Cardiovascular Research·Maarten Hulsmans, Paul Holvoet
Jan 16, 2013·Current Opinion in Rheumatology·Meryem AmmariFlorence Apparailly
Jan 18, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Gang Liu, Edward Abraham
May 16, 2014·The Journal of Endocrinology·Cho-Rong BaeYukari Date
Apr 1, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L YuZ Wu
Jan 26, 2016·American Journal of Reproductive Immunology : AJRI·John E SchjenkenSarah A Robertson
Nov 5, 2014·Expert Opinion on Drug Delivery·Thanh-Huyen Tran, Mansoor M Amiji
Jan 23, 2016·International Immunopharmacology·Cheng HuangJun Li
Sep 4, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Amanda C Lepp, Robert L Carlone
Jan 16, 2016·Digestive Diseases and Sciences·Gyongyi Szabo, Timea Csak
Aug 28, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J A Deiuliis
Oct 10, 2015·Biochemical and Biophysical Research Communications·Wanlu ZhangCuifang Wang
Dec 17, 2014·Journal of Oral Science·Yorimasa OgataHideki Takai
Dec 5, 2015·Frontiers in Genetics·Hyun Yong Jin, Changchun Xiao
Sep 27, 2013·Thrombosis and Haemostasis·Simon LeiersederStefan Engelhardt
Jun 30, 2015·The American Journal of Pathology·Amitava DasSashwati Roy
Oct 6, 2015·The Journal of Clinical Investigation·Wei YingBeiyan Zhou
Sep 10, 2015·Current Obesity Reports·Ira IndrakusumaJürgen Eckel
Jun 19, 2013·Journal of Internal Medicine·M HaneklausS L Masters
Feb 5, 2014·British Journal of Pharmacology·T A M AlmabroukS Kennedy
Mar 26, 2016·Molecular and Cellular Endocrinology·Lulu LiuQian Ge
Oct 17, 2014·Immunological Reviews·Sophie ColinBart Staels
Aug 8, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Margaret Alexander, Ryan M O'Connell
Nov 13, 2015·Seminars in Immunology·Chiara PortaAntonio Sica
Aug 9, 2015·Current Opinion in Immunology·Heather H Pua, K Mark Ansel
Apr 7, 2015·Obesity Research & Clinical Practice·Dezhong WenLi Wang
Jul 5, 2015·European Journal of Pharmacology·Min YinChantal M Boulanger
May 5, 2016·Mediators of Inflammation·Theodore S Kapellos, Asif J Iqbal
Oct 10, 2013·Clinical Science·Kasey C VickersFatiha Tabet

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

© 2021 Meta ULC. All rights reserved