A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells

International Immunology
Tomoya KatakaiAkira Shimizu

Abstract

For efficient adaptive immunity, the lymph nodes (LNs) are equipped with a strategically organized microarchitecture, which is largely supported by the reticular network (RN). The RN can be clearly visualized by fluorescence immunohistochemistry coupled with confocal imaging using a monoclonal antibody, ER-TR7, and can be subdivided into four structurally distinct regions, each of which correlates well with the location of distinct immune cell subsets. In addition, we noticed a characteristic reticular structure designated the 'cortical ridge' at the boundary of the T and B zone, in which dendritic cells are preferentially accumulated. In vitro adhesion assays of frozen sections demonstrated a preference of dendritic cells for the cortical ridge rather than the deeper cortex. Adoptive transfer experiments also demonstrated that antigen-bearing dendritic cells migrated to this region from peripheral tissues, especially in the vicinity of the high endothelial venules, and were anchored on the reticular fibers waiting to interact with the antigen-specific T cells. Taken together, the findings obtained in this study provide new insights into how the LN stromal reticulum works as a specialized 'immuno-platform' for tissue compartmen...Continue Reading

Citations

Nov 3, 2010·Histochemistry and Cell Biology·Nobuko TokudaYuji Owada
Jun 21, 2006·Medical Microbiology and Immunology·Uwe Ritter, Anke Osterloh
Mar 4, 2008·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Masanari KoderaDouglas A Steeber
Apr 24, 2008·Immunology and Cell Biology·Lois L Cavanagh, Wolfgang Weninger
Aug 20, 2008·Immunology and Cell Biology·Gib Bogle, P Rod Dunbar
Aug 20, 2008·Nature Immunology·Shannon K BromleyAndrew D Luster
Jan 15, 2008·Nature Immunology·Heather D HickmanJonathan W Yewdell
Oct 1, 2008·Nature Reviews. Immunology·Tobias JuntBurkhard Ludewig
Aug 1, 2009·Nature Reviews. Immunology·Scott N Mueller, Ronald N Germain
Apr 11, 2007·Immunology and Cell Biology·Joost B BeltmanRob J de Boer
May 3, 2012·Proceedings of the National Academy of Sciences of the United States of America·Cherie T NgMichael B A Oldstone
Sep 24, 2004·The Journal of Experimental Medicine·Tomoya KatakaiAkira Shimizu
Mar 1, 2006·The Journal of Experimental Medicine·Marc BajénoffNicolas Glaichenhaus
Mar 29, 2007·The Journal of Experimental Medicine·Joost B BeltmanRob J de Boer
May 9, 2007·The Journal of Experimental Medicine·François Asperti-BoursinEmmanuel Donnadieu
Nov 2, 2011·The Journal of Experimental Medicine·Heather D HickmanJonathan W Yewdell
Mar 23, 2006·Annual Review of Immunology·Flora Castellino, Ronald N Germain
Jan 5, 2008·Annual Review of Immunology·Michael D Cahalan, Ian Parker
Jan 22, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·R C MifflinD W Powell
Jan 21, 2011·Theoretical Biology & Medical Modelling·Virginia A FolcikClay B Marsh
Nov 10, 2005·Arthritis Research & Therapy·Clemens Scheinecker
May 16, 2014·Journal of Immunology Research·H G Alvarenga, L Marti
Apr 3, 2014·The Journal of Clinical Investigation·Kristi J WarrenBryna E Burrell
Apr 17, 2013·Prostaglandins & Other Lipid Mediators·Michiko KawamuraYoshiteru Harada
May 23, 2012·Trends in Immunology·Ming ZengTimothy W Schacker
Jun 21, 2011·Advanced Drug Delivery Reviews·Ivy Pal, Joshua D Ramsey
Dec 15, 2010·Trends in Immunology·Anne L FletcherShannon J Turley
Nov 9, 2010·European Journal of Radiology·Nazanin FarshchianHamid-Reza Mohammadi-Motlagh
Jun 2, 2009·Current Opinion in Immunology·Tri Giang PhanJason G Cyster
Jun 13, 2009·Journal of Immunological Methods·Joost B BeltmanAthanasius F M Marée
Nov 13, 2015·Biomaterials·Ibrahim T Ozbolat, Monika Hospodiuk
Feb 5, 2008·Seminars in Immunology·Zerina LokmicLydia Sorokin
Oct 17, 2007·Journal of Biomedical Materials Research. Part a·Agnieszka N Stachowiak, Darrell J Irvine
Feb 16, 2008·Immunological Reviews·Tim Lämmermann, Michael Sixt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.