A novel retinal biomarker for Parkinson's disease: Quantifying the foveal pit with optical coherence tomography

Movement Disorders : Official Journal of the Movement Disorder Society
Samantha SlotnickIvan Bodis-Wollner

Abstract

Optical coherence tomography offers a potential biomarker tool in Parkinson's disease (PD). A mathematical model quantifying symmetry, breadth, and depth of the fovea was applied. Nintey-six subjects (72 PD and 24 healthy controls) were included in the study. Macular scans of each eye were obtained on two different optical coherence tomography devices: Cirrus and RTVue. The variables corresponding to the cardinal gradients of the fovea were the most sensitive indicators of PD for both devices. Principal component analysis distinguished 65% of PD patients from controls on Cirrus, 57% on RTVue. Parkinson's disease shallows the superior/inferior and to a lesser degree nasal-temporal foveal slope. The symmetry, breadth, and depth model fits optical coherence tomography data derived from two different devices, and it is proposed as a diagnostic tool in PD.

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Citations

Feb 9, 2017·Pharmacology & Therapeutics·Christine T O NguyenMagnus Ivarsson
May 9, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Isabel Ortuño-LizaránNicolás Cuenca
Jun 4, 2018·Investigative Ophthalmology & Visual Science·Atsuro UchidaJustis P Ehlers
Oct 13, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Li GuoM Francesca Cordeiro
Dec 15, 2018·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Sangeetha Srinivasan, Nathan Efron
Jul 18, 2020·Journal of Neural Transmission·Elmar H PinkhardtIvan Bodis-Wollner
May 29, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Ane Murueta-GoyenaIñigo Gabilondo
Dec 14, 2019·Therapeutic Advances in Chronic Disease·Timothy E YapM Francesca Cordeiro
Aug 27, 2018·Journal of Neural Transmission·Ilaria Cova, Alberto Priori

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