A novel role for interleukin-18 in human natural killer cell death: high serum levels and low natural killer cell numbers in patients with systemic autoimmune diseases

Arthritis and Rheumatism
K ShibatomiKatsumi Eguchi

Abstract

Patients with systemic autoimmune diseases have been reported to have reduced numbers of peripheral blood natural killer (NK) cells compared with healthy subjects. The ability of selected cytokines to trigger NK cell death prompted us to compare the levels of peripheral blood cytokines with the numbers of NK cells in patients with various systemic autoimmune diseases. We used enzyme-linked immunosorbent assays to measure the concentration of selected cytokines (interleukin-18 [IL-18], IL-15, IL-12, IL-2, interferon-gamma [IFNgamma], and tumor necrosis factor alpha [TNFalpha]) in sera from 58 patients with systemic autoimmune diseases and 33 healthy controls. The absolute number of T cells and NK cells in the peripheral blood was measured in parallel using flow cytometry. The ability of selected cytokines to induce NK cell death was then measured using 3,3'-dihexyloxacarbocyanine iodide dye, propidium iodide staining, and caspase 3 activity. Levels of IL-18, IL-15, IFNgamma, and TNFalpha were elevated in sera from patients with systemic autoimmune diseases compared with normal controls. The percentage of NK cells and natural killer T cells were significantly decreased in the peripheral blood of patients with systemic autoimmune ...Continue Reading

References

Jan 1, 1989·Advances in Immunology·G Trinchieri
Oct 1, 1984·Arthritis and Rheumatism·W L SibbittA D Bankhurst
Aug 1, 1983·Arthritis and Rheumatism·N MiyasakaN Talal
Jan 1, 1980·Arthritis and Rheumatism·T Hoffman
Jan 1, 1995·The Journal of Experimental Medicine·J R OrtaldoJ J O'Shea
Jan 1, 1996·Annual Review of Immunology·M FeldmannR N Maini
Mar 1, 1997·The Journal of Clinical Investigation·W E CarsonM A Caligiuri
Dec 31, 1997·The Journal of Experimental Medicine·B ZhangT Tabira
May 16, 1998·European Journal of Immunology·H Ida, P Anderson
May 23, 1998·Annual Review of Immunology·L L Lanier
Jun 8, 1999·Annual Review of Immunology·C A BironT P Salazar-Mather
Oct 20, 1999·Methods : a Companion to Methods in Enzymology·C A Dinarello
Nov 11, 1999·Arthritis and Rheumatism·A KawakamiK Eguchi
Nov 24, 1999·The Journal of Clinical Investigation·J A GracieI B McInnes
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·S KimW M Yokoyama
Jun 17, 2000·Arthritis and Rheumatism·W E Seaman

❮ Previous
Next ❯

Citations

Dec 25, 2012·Rheumatology International·Wang-Dong XuDong-Qing Ye
Oct 10, 2006·Modern Rheumatology·Hiroaki IdaKatsumi Eguchi
Dec 23, 2003·Immunology Letters·Kiyoshi MigitaKatsumi Eguchi
Dec 4, 2003·The Journal of Laboratory and Clinical Medicine·Koto NakashimaKatsumi Eguchi
Sep 26, 2006·Nature Reviews. Immunology·Fu-Dong Shi, Luc Van Kaer
Jan 8, 2011·International Immunology·Anna LünemannChristian Münz
Jul 16, 2009·Molecular Medicine·Anna LünemannChristian Münz
May 11, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Masaki ShimizuAkihiro Yachie
May 4, 2011·Autoimmunity Reviews·Paola ConigliaroRoberto Perricone
Nov 3, 2010·Molecular Immunology·Yong HuangAndrew Dayton
May 30, 2009·Arthritis and Rheumatism·Yong-Wook ParkHyung-Sik Kang
Sep 18, 2009·Annals of the New York Academy of Sciences·Flavia FavilliPaola Migliorini
Feb 16, 2005·Journal of Neuroimmunology·Giuseppe TringaliPierluigi Navarra
May 16, 2006·The Journal of Laboratory and Clinical Medicine·Yasumori IzumiKatsumi Eguchi
May 16, 2003·American Journal of Obstetrics and Gynecology·Kristina M AdamsM Wendy Atkinson
Jun 21, 2014·Cytokine & Growth Factor Reviews·Anneleen AvauPatrick Matthys
Mar 10, 2017·Trends in Immunology·Peter A Morawski, Silvia Bolland
Dec 17, 2017·Immunological Reviews·Gilles Kaplanski
Jun 26, 2004·Journal of Leukocyte Biology·Ali Ahmad, Fernando Alvarez
Apr 17, 2013·The Journal of Rheumatology·Raffaele StrippoliFabrizio De Benedetti
Jan 29, 2020·Clinical and Experimental Immunology·S L McQuaidP A Johnson
Dec 31, 2014·Journal of Leukocyte Biology·Marina FabbiSilvano Ferrini
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ruolan LiuFu-Dong Shi
Jun 26, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elisaveta VoynovaSilvia Bolland
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E EsfandiariF Y Liew
Oct 24, 2017·Clinical and Experimental Immunology·D de J Cruz-GonzálezA E Monsiváis-Urenda
Jun 14, 2019·Current Opinion in Rheumatology·Giusi PrencipeFabrizio De Benedetti
Mar 20, 2012·Cancer Research·Magali TermeLaurence Zitvogel
Jul 5, 2011·Cancer Research·Magali TermeLaurence Zitvogel
May 14, 2021·Immunological Medicine·Masaki Shimizu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.