A novel role for retrograde transport of microtubules in the axon

Cytoskeleton
Peter W Baas, Olga I Mozgova

Abstract

Short microtubules move within the axon in both directions. In the past, it had been assumed that all of the short moving microtubules are oriented with their plus-ends distal to the cell body, regardless of their direction of movement. The anterogradely moving microtubules were posited to play critical roles in the establishment, expansion, and maintenance of the axonal microtubule array. There was no known function for the retrogradely moving microtubules. In considering the mechanism of their transport, we had assumed that all of the short microtubules have a plus-end-distal polarity orientation, as is characteristic of the long microtubules that dominate the axon. Here we discuss an alternative hypothesis, namely that the short microtubules moving retrogradely have the opposite polarity orientation of those moving anterogradely. Those that move anterogradely have their plus-ends distal to the cell body while those that move retrogradely have their minus ends distal to the cell body. In this view, retrograde transport is a means for clearing the axon of incorrectly oriented microtubules. This new model, if correct, has profound implications for the manner by which healthy axons preserve their characteristic pattern of microt...Continue Reading

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Citations

Oct 5, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shen LinPeter W Baas
Jul 3, 2013·Brain : a Journal of Neurology·Peter W Baas, Fridoon J Ahmad
Nov 26, 2013·Journal of Neurochemistry·Erik W Dent, Peter W Baas
Jul 23, 2015·Neural Regeneration Research·Peter W Baas, Andrew J Matamoros
Oct 26, 2016·Brain Research Bulletin·Andrew J Matamoros, Peter W Baas
Oct 6, 2017·Molecular Biology of the Cell·Erin M CraigPeter W Baas
Jan 22, 2019·Soft Matter·Kunalika JainChaitanya A Athale
Sep 15, 2018·Disease Models & Mechanisms·Clément PlaudAndrea Burgo
Jun 15, 2018·Nature Communications·Francisco FreixoJens Lüders
Nov 2, 2018·Investigative Ophthalmology & Visual Science·Denis SharoukhovHyungsik Lim
Apr 5, 2021·Neuroscience Letters·Shrobona GuhaPeter W Baas
Dec 5, 2017·Trends in Neurosciences·Anand N Rao, Peter W Baas
Apr 25, 2015·Journal of Cell Science·Ashley L ArthurJill Wildonger

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