A novel role for thioredoxin reductase in the iron metabolism of S. cerevisiae

Biochemical and Biophysical Research Communications
Hyun-Jun KangCheol-Won Yun

Abstract

Intracellular levels of iron are tightly regulated. Saccharomyces cerevisiae uses well-defined pathways to extract iron molecules from the environment. Once inside the cell, the iron molecules must be transferred to target sites via an intracellular iron transporter. Although analogous carriers have been described for other metals, such as copper, an iron transporter has yet to be identified. We used two-dimensional gel electrophoresis and mass spectrometry techniques to attempt to identify the iron transporter from cytosolic fraction of S. cerevisiae. In this study, we identified the iron-binding activity of thioredoxin reductase, and our data suggest a potential role for this enzyme in intracellular iron transport.

References

Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·H Ding, B Demple
Aug 26, 1998·Annual Review of Nutrition·D J Eide
Jul 27, 2002·Annual Review of Microbiology·Anthony Van HoJerry Kaplan
May 21, 2003·Critical Reviews in Clinical Laboratory Sciences·Jayong Chung, Marianne Wessling-Resnick
Jan 15, 2004·The Biochemical Journal·Huangen Ding, Robert J Clark
Mar 23, 2004·Physiologia Plantarum·Glen L. Wheeler, Chris M. Grant
Aug 23, 2005·Molecular Aspects of Medicine·Miguel Arredondo, Marco T Núñez
Oct 8, 2005·Expert Review of Proteomics·Xuesong SunQing-Yu He
Oct 11, 2005·Journal of Proteome Research·Ida Chiara GuerreraJasminka Godovac-Zimmermann
Dec 13, 2005·Free Radical Biology & Medicine·Jason M HansenDean P Jones
Mar 28, 2006·Biochemical and Biophysical Research Communications·Maria Pia RigobelloAlberto Bindoli
May 16, 2006·Biochimica Et Biophysica Acta·Jerry KaplanCaroline C Philpott
Aug 1, 2006·The Journal of Biological Chemistry·Juanjuan YangHuangen Ding

❮ Previous
Next ❯

Citations

Aug 12, 2014·Biochemical Society Transactions·Carmelina Petrungaro, Jan Riemer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.