A novel role of alkaline phosphatase in protection from immunological liver injury in mice

Liver
Qiang XuXianming Zhang

Abstract

Little is known about the role of alkaline phosphatase (AP) in liver diseases, except for its elevation in jaundice or cholestasis. Its substrate, endotoxin, is usually elevated in patients as well as animals with liver damage. This study aimed to provide evidence for its new role as protection against immunological liver damage. Liver injury was induced in mice by delayed-type hypersensitivity to picryl chloride. AP activity was measured using a commercial kit. In acute liver injury, a significant decrease in AP activity in serum was observed but there was an increase in liver tissue. Single administration of cyclophosphamide before sensitization with picryl chloride exacerbated the liver injury, with more serious AP changes, while consecutive use after the sensitization alleviated the injury with a recovery from the changes. When liver injury proceeded for 1 week, both serum and liver showed decreased AP activity. Lipopolysaccharide facilitated alanine transaminase release from levamisole-pretreated but not non-treated hepatocytes from naive mice. However, the release was confirmed from liver slices of mice with liver injury proceeding for 1 week, even without levamisole pretreatment. The development of liver injury may lead ...Continue Reading

References

Aug 1, 1987·Clinical Biochemistry·D W Moss
Mar 1, 1988·Japanese Journal of Pharmacology·H NagaiM Kasahara
Jan 1, 1986·Biochemical Pharmacology·D W Siemann, R T Mulcahy
Jul 1, 1995·Immunobiology·H W Ziegler-HeitbrockA Wedel
Apr 1, 1997·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Q XuX Chen
Jan 27, 1998·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Q XuF Wu
Dec 29, 2000·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·X ChenQ Xu

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Citations

Mar 2, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Farzad EbrahimiRichard A Hodin
Aug 28, 2012·The Journal of Biological Chemistry·Bernard P ArulanandamJames P Chambers
Jun 24, 2005·Infection and Immunity·Suzanne Q van VeenThomas M van Gulik
Nov 29, 2015·Chemico-biological Interactions·Sohair R FahmySara M Elaskalany
Sep 17, 2003·International Journal of Experimental Pathology·Jola J KapojosWinston W Bakker

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