A novel scale to assess psychosis in patients with parkinson's disease

Journal of Clinical Movement Disorders
William G OndoMinJae Lee

Abstract

Organic psychosis effects up to 70 % of patients with PD at some point yet no widely accepted scale for this entity exists. We developed a 10 question PD specific psychosis severity scale that we feel has good content validity. It asks about the presence, severity, frequency, and consequences of the hallucinations (visual, auditory, olfactory) and delusions. Fifty different PD patients with psychosis and 25 PD patients without psychosis were included, and serial information was available in 21 of those encounters with psychosis. In psychosis subjects, results were normally distributed: mean 17.23 (SD = 6.30). In those without psychosis 14 % scored >0, mean 0.36 [range0-7]. The intra-rater, inter-class correlation coefficient was excellent (N = 21 pairs of observations seven days apart, ICC = 0.87). Inter-rater reliability (two different raters, N = 46 pairs) was outstanding for the entire group, ICC = 0.92). As expected visual hallucinations were most common (mean = 3.13). The presence of delusions was associated with greater total scores. This scale, specifically designed for PD psychosis is easy to administer and has impressive metrics.

References

Mar 11, 1999·The New England Journal of Medicine·UNKNOWN Parkinson Study Group
Oct 3, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·William G OndoJoseph Jankovic
Dec 25, 2003·Lancet Neurology·Ian McKeithUNKNOWN International Psychogeriatric Association Expert Meeting on DLB
Apr 1, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·William G OndoGeorge Ringholz
Jan 30, 2010·Parkinsonism & Related Disorders·Christopher G Goetz
Jun 12, 2010·Parkinsonism & Related Disorders·Joseph H Friedman
Sep 17, 2011·Brain : a Journal of Neurology·David A GallagherAnette Schrag

❮ Previous
Next ❯

Citations

Jan 28, 2018·Current Psychiatry Reports·Shyam C Panchal, William G Ondo
Sep 11, 2020·The International Journal of Neuroscience·Jessica GregerHoracio Capote
Jun 3, 2018·Journal of Neural Transmission·Abhishek LenkaPramod Kumar Pal

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
R Sandyk
Annales médico-psychologiques
J ALLIEZ, R PUJOL
Neurology
Steven J Frucht, Lorin Bernsohn
© 2022 Meta ULC. All rights reserved