A novel selective broad-spectrum anti-DNA virus agent

Nature
E De ClercqP C Maudgal

Abstract

A new compound has been found, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine ((S)-HPMPA), that has potent and selective activity against a broad spectrum of DNA viruses, including herpes simplex virus (types 1 and 2); varicella zoster virus; thymidine kinase-deficient (TK-) mutants of herpes simplex and varicella zoster virus; human cytomegalovirus; phocid, simian, suid, bovid and equid herpesviruses; African swine fever virus; vaccinia virus; and human adenoviruses. It is also active against retroviruses. We also report that, in mice and rabbits in vivo, the compound is effective against both local and systemic infections with herpes simplex virus type 1, including herpetic keratitis caused by a TK- mutant which is resistant to the classical anti-herpes drugs.

References

Dec 9, 1985·Nucleic Acids Research·D W Hutchinson, M Naylor
Mar 15, 1985·Science·R Dolin
May 16, 1985·Biochemical and Biophysical Research Communications·R L TolmanE M Scolnick
May 31, 1985·Biochemical and Biophysical Research Communications·E De Clercq, M Cools
Sep 1, 1985·Annals of Internal Medicine·D FelsensteinR T Schooley
Jan 15, 1986·Biochemical Pharmacology·C E NakamuraR E Parks
Jun 1, 1985·The Journal of Antimicrobial Chemotherapy·A Bauernfeind
Nov 1, 1985·Journal of Medicinal Chemistry·H GrienglB Rosenwirth
May 1, 1980·The Journal of Infectious Diseases·E De ClercqD Shugar
Feb 11, 1982·The New England Journal of Medicine·C S CrumpackerM J Levin
Nov 1, 1982·The Journal of Infectious Diseases·C D SibrackD W Barry
May 1, 1983·Journal of Medicinal Chemistry·J C MartinJ P Verheyden
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A K FieldR L Tolman
May 1, 1983·Antimicrobial Agents and Chemotherapy·D F SmeeT R Matthews
Oct 1, 1983·Antimicrobial Agents and Chemotherapy·E C MarE S Huang
Feb 1, 1984·Antimicrobial Agents and Chemotherapy·M J TocciA K Field
Apr 1, 1984·Antiviral Research·B A Larder, G Darby
Jun 1, 1984·Antiviral Research·E De ClercqJ A Montgomery

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Citations

May 20, 1998·International Journal of Cancer. Journal International Du Cancer·S HatseJ Balzarini
Jul 9, 1999·Reviews in Medical Virology·S SafrinH S Jaffe
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·S LiekensJ Neyts
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·X XiongC S Gibbs
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M TsiangC S Gibbs
May 7, 2002·Journal of Medical Virology·Ilse StragierHugo De Greef
Dec 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R SnoeckE De Clercq
Feb 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G AndreiE De Clercq
Aug 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R SnoeckE De Clercq
Apr 1, 1993·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J NeytsE De Clercq
Jun 1, 1993·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J NeytsE De Clercq
Dec 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G AndreiE De Clercq
Apr 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G AndreiE De Clercq
Apr 1, 1996·Molecular Biotechnology·S Freeman, J M Gardiner
Jan 13, 1994·Biochemical Pharmacology·J Neyts, E De Clercq
Jul 1, 1994·International Journal for Parasitology·A Makioka, J Ellis
Oct 1, 1989·Veterinary Immunology and Immunopathology·L WillemsG Meulemans
Aug 1, 1989·Antiviral Research·E De Clercq
May 1, 1990·Journal of Virology·D R YagerD M Coen

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