A novel serine/threonine kinase gene, Gek1, is expressed in meiotic testicular germ cells and primordial germ cells

Molecular Reproduction and Development
M YanagisawaY Matsui

Abstract

We have isolated a novel serine/ threonine kinase gene designated Gek1 from mouse primordial germ cell-derived embryonic germ cell. Gek1 is preferentially expressed in meiotic testicular germ cells and primordial germ cells. Gek1 mRNA is also detected in several other tissues, including hematopoietic organs in adult mice and central nervous system in embryos. The Gek1 cDNA encodes a protein with the consensus sequence of the catalytic domain of protein kinases in its N-terminal region. The deduced amino acid sequence of Gek1 in the kinase domain is related to those encoded by the Saccharomyces cerevisiae STE20, CDC15, and Drosophila melanogaster ninaC. The patterns of expression and the structural features of Gek1 suggest that the gene product is involved in signal transduction or nuclear division of germ cells and other proliferating cells. We also show that Gek1 locates on chromosome 11, near the wr locus, showing neuronal and reproductive defects.

References

Jan 1, 1975·Journal of Neuropathology and Experimental Neurology·J M Andrews
Dec 1, 1991·Genes & Development·S LlamazaresC E Sunkel
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M A FrohmanG R Martin
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A F Wilks
Dec 1, 1968·Journal of Neurology, Neurosurgery, and Psychiatry·L W Duchen, S J Strich
Jan 1, 1994·Developmental Biology·A I PackerR F Bachvarova
Aug 1, 1995·Molecular Reproduction and Development·N MatsubaraY Matsui
Apr 1, 1995·Developmental Biology·U KoshimizuN Nakatsuji
Dec 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·T WatanabeD Solter
Jun 1, 1994·Nature Genetics·W F DietrichR D Dredge
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·U HoltrichK Strebhardt
Dec 11, 1993·Nucleic Acids Research·I HatadaT Mukai
Feb 1, 1993·Current Opinion in Genetics & Development·N YewG F Vande Woude
May 1, 1993·Developmental Biology·M De FeliciM Pesce
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S W Ramer, R W Davis
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·Y Iino, M Yamamoto
Jan 1, 1985·Molecular & General Genetics : MGG·Y Lino, M Yamamoto

❮ Previous
Next ❯

Citations

Nov 14, 2006·FEBS Letters·Masaki Kawamata, Katsuhiko Nishimori
May 12, 2019·Biology of Reproduction·Jessica Y ChotinerP Jeremy Wang
Aug 1, 2008·Biology of Reproduction·Sarah M KehoeNaohiro Terada
Aug 19, 2017·The Journal of Cell Biology·Qing-Hua ZhangJohn Carroll
Apr 13, 2012·Biology of Reproduction·Jianguan WangTian Chi
Apr 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Debra J Wolgemuth, Shelby S Roberts

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.