A novel serum marker, total prostate secretory protein of 94 amino acids, improves prostate cancer detection and helps identify high grade cancers at diagnosis

The Journal of Urology
Robert K NamSteven A Narod

Abstract

New biomarkers for prostate cancer are needed. We determined whether a novel serum marker, total PSP94 can be used to accomplish these goals. We conducted a case-control study of 1,212 men with no previous history of prostate cancer and who underwent a prostate biopsy from 1998 to 2000 because of an increased PSA or an abnormal DRE. Serum PSP94 levels were assessed using a sandwich enzyme-linked immunosorbent assay technique. Cases were patients with prostate cancer, and controls were patients who had no evidence of cancer. Multivariate logistic regression analysis was used to determine whether or not PSP94 levels improved the predictive value for prostate cancer. Of the 1,212 men 596 (49.2%) had cancer detected. The median PSP94 level was significantly lower among cases (2.60 ng/ml) than among controls (3.40 ng/ml, p <0.0001). The adjusted odds ratios for the presence of prostate cancer for patients with the lowest quartile of PSP94, compared to patients in the highest quartile was 2.70 (95% CI 1.8 - 4.0, p <0.0001). Among a subgroup of 649 men in whom PSA had a low predictive value (PSA less than 20 ng/ml, normal DRE and less than 70 years), 260 (40.1%) were found to have cancer. In this subgroup total PSP94 levels helped dis...Continue Reading

References

Oct 8, 1987·The New England Journal of Medicine·T A StameyE Redwine
Jan 1, 1996·European Urology·W A SakrJ D Crissman
Aug 24, 1999·Cancer Metastasis Reviews·M PollakJ C Zhang
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert K NamSteven A Narod
May 28, 2004·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman

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Citations

Nov 26, 2010·Asian Journal of Andrology·Aleyde Van EyndeMathieu Bollen
Feb 12, 2008·Nature Genetics·Gilles ThomasStephen J Chanock
Dec 6, 2012·Journal of the National Cancer Institute·Christopher A HaimanHans Lilja
Dec 14, 2011·The Cancer Journal·Mark M Pomerantz, Matthew L Freedman
Apr 4, 2009·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Mukesh KumarM Ramanadham
Mar 26, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kevin M WatersChristopher A Haiman
Sep 10, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Timothy R RebbeckCharnita M Zeigler-Johnson
Aug 26, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kevin M WatersChristopher A Haiman
Aug 11, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Xing XuRobert J Klein
Nov 13, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Bao-Li ChangTimothy R Rebbeck
Jul 20, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anders S BjartellPeter T Scardino
Aug 3, 2010·Asian Journal of Andrology·Bhakti R PathakSmita D Mahale
Feb 5, 2013·Biochimica Et Biophysica Acta·Ananya A BreedBhakti R Pathak
Sep 8, 2010·Hematology/oncology Clinics of North America·Zsofia K StadlerKenneth Offit
May 1, 2007·Protein Expression and Purification·Seema GardeMadhulika B Gupta
Jul 1, 2009·Expert Opinion on Medical Diagnostics·Carlos H MartínezJoseph Chin
Dec 13, 2016·British Medical Bulletin·S Benafif, R Eeles
Aug 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert K NamMichael W Kattan
Oct 18, 2008·Clinical Chemistry·Girish SardanaEleftherios P Diamandis
Mar 5, 2016·PloS One·Liisa SjöblomTapio Visakorpi
Sep 16, 2015·Molecular and Cellular Biochemistry·Bhakti R PathakSmita D Mahale
Jul 28, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chengdong WangHui Zhao
May 10, 2011·Urologia·Elio DefilippiAlessandro Tizzani

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