PMID: 8469399Feb 5, 1993Paper

A novel silent variant at codon 711 and a variant at codon 708 of the APP sequence detected in Spanish Alzheimer and control cases

Neuroscience Letters
R AdroerL Fidani

Abstract

Pathogenic mutations have been identified in exons 16 and 17 of the beta-amyloid precursor protein (APP) gene in some cases of early onset Alzheimer's disease. Screening of these exons in a number of familial and sporadic cases of Alzheimer's disease in Spain, resulted in the identification of a novel silent variant at codon 711 whose relevance to the AD pathogenesis remains unclear. The 708 variant was also detected in one of normal controls.

References

Apr 18, 1991·Nature·R E Tanzi, B T Hyman

❮ Previous
Next ❯

Citations

Mar 1, 1994·Metabolic Brain Disease·A LeBlanc
Jan 15, 1995·Biological Psychiatry·E JönssonG Sedvall
Jan 3, 1994·Neuroscience Letters·M MortillaP Servi
Apr 21, 1995·Neuroscience Letters·R AdroerR Oliva
Jan 1, 2011·Case Reports in Urology·Jalal Eddine El AmmariM Hassan Farih
Oct 1, 1994·Reviews in the Neurosciences·F CoriaC Bayón

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.