DOI: 10.1101/473090Nov 19, 2018Paper

A novel somatosensory spatial navigation system outside the hippocampal formation

BioRxiv : the Preprint Server for Biology
Xiaoyang Long, Sheng-Jia Zhang

Abstract

Spatially selective firing in the forms of place cells, grid cells, border cells and head direction cells are basic building blocks of a canonical spatial circuit centered on the hippocampal-entorhinal complex. While head direction cells can be found throughout the brain, spatial tuning outside of the parahippocampal regions are often non-specific or conjunctive to other representations such as a reward. While the precise mechanism of spatially selective activities is not understood, various studies show sensory inputs (particularly vision) heavily modulate spatial representation in the hippocampal-entorhinal circuit. To better understand the contribution from other sensory inputs in shaping spatial representation in the brain, we recorded from the hindlimb region of the primary somatosensory cortex (S1HL) in foraging rats. To our surprise, we were able to identify the full complement of spatial activity patterns reported in the hippocampal-entorhinal circuit, namely, place cells, head direction cells, boundary vector/border cells, grid cells and conjunctive cells. This novel finding supports the hypothesis that location information is necessary for body representation in the S1, and may be analogous to spatially tuned represen...Continue Reading

Related Concepts

Cognition
Hippocampus (Brain)
Memory
Microelectrodes
Somatosensory Cortex
Spatial Distribution
Temporal Lobe
Medial
Site
Anatomical Space Structure

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