A novel spermatogenesis-specific uPAR gene expressed in human and mouse testis

Biochemical and Biophysical Research Communications
Xiaokun TengXiangying Kong

Abstract

The urokinase receptor, uPAR, which binds to the urinary-type plasminogen activator, controls matrix degradation in the processes of tissue remodeling, cell migration, and invasion. In the present study, we found a new urokinase receptor gene that encodes a 249-amino acid putative protein. Northern blot analysis showed specific expression in the testis of this gene, which we named the spermatogenesis-related gene (SGRG). In situ hybridization revealed a strong expression signal for SGRG in spermatogonia, but not in spermatocytes. Therefore, we conjecture that SGRG may regulate spermatocyte migration through breakdown of extracellular matrix protein barriers in spermatogenesis. Since SGRG is specifically expressed in spermatogonia, it provides an attractive candidate for development of a contraceptive vaccine.

References

May 1, 1982·Molecular and Cellular Endocrinology·M Lacroix, I B Fritz
May 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S C NewtonC F Millette
May 29, 1999·British Journal of Nursing : BJN·J Wilkinson
Jan 13, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H SolbergL R Lund
Feb 16, 2005·Thrombosis and Haemostasis·Daniela AlfanoMaria Patrizia Stoppelli

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Citations

Nov 22, 2013·Science Translational Medicine·Andrei P DrabovichEleftherios P Diamandis
Mar 7, 2014·Molecular Human Reproduction·D DjureinovicF Pontén
Mar 23, 2007·Biochemical and Biophysical Research Communications·Mei-ling LiuMeng-chun Jia
Jun 22, 2010·International Journal of Andrology·L JaroszynskiP H Vogt
Apr 22, 2016·Human Genomics·Chelsea L LoughnerShivalingappa K Swamynathan
Mar 13, 2020·Frontiers in Cell and Developmental Biology·Katarzyna KentThomas X Garcia

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