A novel statistical analysis method to improve the detection of hepatic foci of (111)In-octreotide in SPECT/CT imaging

EJNMMI Physics
Tobias MagnanderPeter Bernhardt

Abstract

Low uptake ratios, high noise, poor resolution, and low contrast all combine to make the detection of neuroendocrine liver tumours by (111)In-octreotide single photon emission tomography (SPECT) imaging a challenge. The aim of this study was to develop a segmentation analysis method that could improve the accuracy of hepatic neuroendocrine tumour detection. Our novel segmentation was benchmarked by a retrospective analysis of patients categorized as either (111)In-octreotide positive ((111)In-octreotide(+)) or (111)In-octreotide negative ((111)In-octreotide(-)) for liver tumours. Following a 3-year follow-up period, involving multiple imaging modalities, we further segregated (111)In-octreotide-negative patients into two groups: one with no confirmed liver tumours ((111)In-octreotide(-)/radtech(-)) and the other, now diagnosed with liver tumours ((111)In-octreotide(-)/radtech(+)). We retrospectively applied our segmentation analysis to see if it could have detected these previously missed tumours using (111)In-octreotide. Our methodology subdivided the liver and determined normalized numbers of uptake foci (nNUF), at various threshold values, using a connected-component labelling algorithm. Plots of nNUF against the threshold i...Continue Reading

References

Nov 18, 2003·Clinical Endocrinology·Yodphat KrauszOra Israel
Jan 10, 2004·Medical Physics·Peter BernhardtEva Forssell-Aronsson
Sep 14, 2004·Acta Oncologica·Eva Forssell-AronssonHåkan Ahlman
Mar 20, 2008·Nuclear Medicine Communications·Arman Rahmim, Habib Zaidi
Apr 1, 2008·European Journal of Nuclear Medicine and Molecular Imaging·May SadikLars Edenbrandt
May 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dik J KwekkeboomEric P Krenning
Nov 11, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·May SadikLars Edenbrandt
Apr 14, 2009·Critical Reviews in Oncology/hematology·Klaas P KoopmansPieter L Jager
May 13, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Emilio BombardieriUNKNOWN Oncology Committee of the EANM
Sep 6, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Lisa BodeiGiovanni Paganelli
Nov 10, 2011·Journal of Nuclear Medicine Technology·Helena R BalonUNKNOWN Society of Nuclear Medicine
Dec 11, 2013·Nature Reviews. Endocrinology·Martijn van EssenDik J Kwekkeboom
Feb 7, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Johanna SvenssonPeter Bernhardt

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Software Mentioned

nNUFTI
CUDA
PhONSAi
OSEM

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