A novel sulfated holostane glycoside from sea cucumber Holothuria leucospilota

Chemistry & Biodiversity
Hua HanXiao-Hua Wang

Abstract

A new sulfated holostane glycoside, leucospilotaside B (1), together with the two related structurally known compounds holothurin B(2) (2) and holothurin B (3), was isolated from sea cucumber Holothuria leucospilota collected from the South China Sea. The structure of 1 was elucidated by spectral analysis (1H-, 13C-, and 2D-NMR, ESI-MS, and HR-ESI-MS) and chemical methods. The compounds 1-3 possess the same disaccharide moiety, but were different in the side chains of the triterpene aglycone. Compound 1 showed significant cytotoxicities against four human tumor cell lines, HL-60, MOLT-4, A-549, and BEL-7402.

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Citations

May 14, 2014·Marine Drugs·Yadollah BahramiChris Franco
Sep 30, 2014·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Magali Honey-EscandónYves Samyn
Dec 24, 2011·Natural Product Reports·John W BluntMichèle R Prinsep
Jun 16, 2012·Chemistry & Biodiversity·Ming-Ping LaWen Zhang

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