A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography

Journal of Chromatography. a
Lizhen QiaoGuowang Xu

Abstract

Glucaminium-based ionic liquids are a new class of recently developed ionic liquids and prepared by functionalizing the amine group of N-methyl-d-glucamine, which renders them good hydrophilicity due to the presence of the glucose structure and charged quaternary ammonium group. In the present study, a glucaminium-based ionic liquid N,N-diallyl-N-methyl-d-glucaminium bromide was synthesized and subsequently bonded to the surface of 3-mercaptopropyl modified silica materials through "thiol-ene" click chemistry. The obtained stationary phase was characterized by elemental analysis and infrared spectroscopy, and then packed as a HPLC column. A mixture of five nucleosides was used to characterize the separation performance of the obtained column under HILIC mode and the column efficiency was determined with cytidine as the test solute, reaching 80,000plates/m. Then, the retention behavior was evaluated by investigating the effect of various chromatographic factors on retention of different types of solutes, and the results revealed that the developed surface-confined glucaminium-based ionic liquid stationary phase exhibited a hydrophilic interaction/anion-exchange mixed-mode retention mechanism. Finally, two mixtures of nucleotides...Continue Reading

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Citations

Oct 16, 2015·Journal of Chromatography. a·Xianzhe ShiGuowang Xu
Apr 17, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sylwia MagieraJacek Baranowski
May 29, 2016·Journal of Pharmaceutical and Biomedical Analysis·Kelly Zhang, Xiaodong Liu
Sep 21, 2016·Journal of Pharmaceutical and Biomedical Analysis·Kelly Zhang, Xiaodong Liu
Aug 25, 2018·Journal of Separation Science·Claudio de Castro FerreiraIsabel Cristina Sales Fontes Jardim
Jan 16, 2021·Biomedical Chromatography : BMC·Elham Sadat Hosseini, Kourosh Tabar Heydar
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valerio ZulloLorenzo Guazzelli

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